TCR-triggered extracellular superoxide production is not required for T-cell activation.

5.00
Hdl Handle:
http://hdl.handle.net/10033/332622
Title:
TCR-triggered extracellular superoxide production is not required for T-cell activation.
Authors:
Belikov, Aleksey V; Schraven, Burkhart; Simeoni, Luca
Abstract:
In the last decade, reactive oxygen species (ROS) production has been shown to occur upon T-cell receptor (TCR) stimulation and to affect TCR-mediated signalling. However, the exact reactive species that are produced, how ROS are generated and their requirement for T-cell activation, proliferation or cytokine production remain unclear, especially in the case of primary human T cells. Moreover, several groups have questioned that ROS are produced upon TCR stimulation.
Citation:
TCR-triggered extracellular superoxide production is not required for T-cell activation. 2014, 12:50 Cell Commun. Signal
Journal:
Cell communication and signaling : CCS
Issue Date:
2014
URI:
http://hdl.handle.net/10033/332622
DOI:
10.1186/s12964-014-0050-1
PubMed ID:
25081034
Type:
Article
Language:
en
ISSN:
1478-811X
Appears in Collections:
publications of the department of immune control (IMMK)

Full metadata record

DC FieldValue Language
dc.contributor.authorBelikov, Aleksey Ven
dc.contributor.authorSchraven, Burkharten
dc.contributor.authorSimeoni, Lucaen
dc.date.accessioned2014-10-09T13:48:19Z-
dc.date.available2014-10-09T13:48:19Z-
dc.date.issued2014-
dc.identifier.citationTCR-triggered extracellular superoxide production is not required for T-cell activation. 2014, 12:50 Cell Commun. Signalen
dc.identifier.issn1478-811X-
dc.identifier.pmid25081034-
dc.identifier.doi10.1186/s12964-014-0050-1-
dc.identifier.urihttp://hdl.handle.net/10033/332622-
dc.description.abstractIn the last decade, reactive oxygen species (ROS) production has been shown to occur upon T-cell receptor (TCR) stimulation and to affect TCR-mediated signalling. However, the exact reactive species that are produced, how ROS are generated and their requirement for T-cell activation, proliferation or cytokine production remain unclear, especially in the case of primary human T cells. Moreover, several groups have questioned that ROS are produced upon TCR stimulation.en
dc.language.isoenen
dc.rightsArchived with thanks to Cell communication and signaling : CCSen
dc.titleTCR-triggered extracellular superoxide production is not required for T-cell activation.en
dc.typeArticleen
dc.identifier.journalCell communication and signaling : CCSen

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