Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application.

2.50
Hdl Handle:
http://hdl.handle.net/10033/337849
Title:
Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application.
Authors:
Nnamani, Petra O; Hansen, Steffi; Windbergs, Maike; Lehr, Claus-Michael
Abstract:
NLC topical formulation as an alternative to oral and parenteral (IM) delivery of artemether (ART), a poorly water-soluble drug was designed. A Phospholipon 85G-modified Gelucire 43/01 based NLC formulation containing 75% Transcutol was chosen from DSC studies and loaded with gradient concentration of ART (100-750mg). ART-loaded NLCs were stable (-22 to -40mV), polydispersed (0.4-0.7) with d90 size distribution range of 247-530nm without microparticles up to one month of storage. The encapsulation efficiency (EE%) for ART in the NLC was concentration independent as 250mg of ART loading achieved ∼61%. DSC confirmed molecular dispersion of ART due to low matrix crystallinity (0.028J/g). Ex vivo study showed detectable ART amounts after 20h which gradually increased over 48h achieving ∼26% cumulative amount permeated irrespective of the applied dose. This proves that ART permeates excised human epidermis, where the current formulation served as a reservoir to gradually control drug release over an extended period of time. Full thickness skin study therefore may confirm if this is a positive signal to hope for a topical delivery system of ART.
Citation:
Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application. 2014, 477 (1-2):208-17 Int J Pharm
Journal:
International journal of pharmaceutics
Issue Date:
30-Dec-2014
URI:
http://hdl.handle.net/10033/337849
DOI:
10.1016/j.ijpharm.2014.10.004
PubMed ID:
25290810
Type:
Article
Language:
en
ISSN:
1873-3476
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorNnamani, Petra Oen
dc.contributor.authorHansen, Steffien
dc.contributor.authorWindbergs, Maikeen
dc.contributor.authorLehr, Claus-Michaelen
dc.date.accessioned2015-01-05T15:52:09Zen
dc.date.available2015-01-05T15:52:09Zen
dc.date.issued2014-12-30en
dc.identifier.citationDevelopment of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application. 2014, 477 (1-2):208-17 Int J Pharmen
dc.identifier.issn1873-3476en
dc.identifier.pmid25290810en
dc.identifier.doi10.1016/j.ijpharm.2014.10.004en
dc.identifier.urihttp://hdl.handle.net/10033/337849en
dc.description.abstractNLC topical formulation as an alternative to oral and parenteral (IM) delivery of artemether (ART), a poorly water-soluble drug was designed. A Phospholipon 85G-modified Gelucire 43/01 based NLC formulation containing 75% Transcutol was chosen from DSC studies and loaded with gradient concentration of ART (100-750mg). ART-loaded NLCs were stable (-22 to -40mV), polydispersed (0.4-0.7) with d90 size distribution range of 247-530nm without microparticles up to one month of storage. The encapsulation efficiency (EE%) for ART in the NLC was concentration independent as 250mg of ART loading achieved ∼61%. DSC confirmed molecular dispersion of ART due to low matrix crystallinity (0.028J/g). Ex vivo study showed detectable ART amounts after 20h which gradually increased over 48h achieving ∼26% cumulative amount permeated irrespective of the applied dose. This proves that ART permeates excised human epidermis, where the current formulation served as a reservoir to gradually control drug release over an extended period of time. Full thickness skin study therefore may confirm if this is a positive signal to hope for a topical delivery system of ART.en
dc.language.isoenen
dc.titleDevelopment of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application.en
dc.typeArticleen
dc.identifier.journalInternational journal of pharmaceuticsen

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