2.50
Hdl Handle:
http://hdl.handle.net/10033/344378
Title:
Antiviral drug discovery: broad-spectrum drugs from nature.
Authors:
Martinez, J P; Sasse, F; Brönstrup, M; Diez, J; Meyerhans, A
Abstract:
Covering: up to April 2014. The development of drugs with broad-spectrum antiviral activities is a long pursued goal in drug discovery. It has been shown that blocking co-opted host-factors abrogates the replication of many viruses, yet the development of such host-targeting drugs has been met with scepticism mainly due to toxicity issues and poor translation to in vivo models. With the advent of new and more powerful screening assays and prediction tools, the idea of a drug that can efficiently treat a wide range of viral infections by blocking specific host functions has re-bloomed. Here we critically review the state-of-the-art in broad-spectrum antiviral drug discovery. We discuss putative targets and treatment strategies, with particular focus on natural products as promising starting points for antiviral lead development.
Affiliation:
Helmholtz Centre for infection research (HZI), Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Antiviral drug discovery: broad-spectrum drugs from nature. 2015, 32 (1):29-48 Nat Prod Rep
Journal:
Natural product reports
Issue Date:
Jan-2015
URI:
http://hdl.handle.net/10033/344378
DOI:
10.1039/c4np00085d
PubMed ID:
25315648
Type:
Article
Language:
en
ISSN:
1460-4752
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorMartinez, J Pen
dc.contributor.authorSasse, Fen
dc.contributor.authorBrönstrup, Men
dc.contributor.authorDiez, Jen
dc.contributor.authorMeyerhans, Aen
dc.date.accessioned2015-02-11T15:58:06Z-
dc.date.available2015-02-11T15:58:06Z-
dc.date.issued2015-01-
dc.identifier.citationAntiviral drug discovery: broad-spectrum drugs from nature. 2015, 32 (1):29-48 Nat Prod Repen
dc.identifier.issn1460-4752-
dc.identifier.pmid25315648-
dc.identifier.doi10.1039/c4np00085d-
dc.identifier.urihttp://hdl.handle.net/10033/344378-
dc.description.abstractCovering: up to April 2014. The development of drugs with broad-spectrum antiviral activities is a long pursued goal in drug discovery. It has been shown that blocking co-opted host-factors abrogates the replication of many viruses, yet the development of such host-targeting drugs has been met with scepticism mainly due to toxicity issues and poor translation to in vivo models. With the advent of new and more powerful screening assays and prediction tools, the idea of a drug that can efficiently treat a wide range of viral infections by blocking specific host functions has re-bloomed. Here we critically review the state-of-the-art in broad-spectrum antiviral drug discovery. We discuss putative targets and treatment strategies, with particular focus on natural products as promising starting points for antiviral lead development.en
dc.language.isoenen
dc.subject.meshAntiviral Agentsen
dc.subject.meshBiological Productsen
dc.subject.meshDrug Delivery Systemsen
dc.subject.meshDrug Discoveryen
dc.subject.meshHumansen
dc.subject.meshMolecular Structureen
dc.titleAntiviral drug discovery: broad-spectrum drugs from nature.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research (HZI), Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalNatural product reportsen

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