2.50
Hdl Handle:
http://hdl.handle.net/10033/346200
Title:
Antibiotic control of tumor-colonizing Salmonella enterica serovar Typhimurium.
Authors:
Crull, Katja; Weiss, Siegfried
Abstract:
Systemic administration of Salmonella enterica serovar Typhimurium (S. typhimurium) into tumor-bearing mice results in preferential colonization of tumors and causes shrinkage and sometimes complete tumor clearance. However, in spite of these beneficial antitumor effects, the systemic administration of a bacterial pathogen raises serious safety concerns as well. Addressing those concerns, here, we demonstrate that tumor-colonizing Salmonella can be readily controlled by systemic administration of the antibiotic - ciprofloxacin. Treatment was most effective when started early postinfection. This was achieved at the expense of the efficacy of tumor therapy. In many of the mice treated in such a way, tumors re-grew again. Nevertheless, some mice were able to clear the tumor despite the start of antibiotic treatment only 24 h after the start of infection. Furthermore, we could demonstrate that such mice had elicited a specific antitumor immune response. Thus, S. typhimurium-mediated tumor therapy might be applied safely when combined with early antibiotic treatment. However, the therapeutic power of the bacteria needs to be enhanced in order to provide a more effective therapeutic tool.
Citation:
Antibiotic control of tumor-colonizing Salmonella enterica serovar Typhimurium. 2011, 236 (11):1282-90 Exp. Biol. Med. (Maywood)
Journal:
Experimental biology and medicine (Maywood, N.J.)
Issue Date:
Nov-2011
URI:
http://hdl.handle.net/10033/346200
DOI:
10.1258/ebm.2011.011111
PubMed ID:
21987828
Type:
Article
Language:
en
ISSN:
1535-3699
Appears in Collections:
publications of the research group molecular Immunology (MOLI)

Full metadata record

DC FieldValue Language
dc.contributor.authorCrull, Katjaen
dc.contributor.authorWeiss, Siegfrieden
dc.date.accessioned2015-03-05T11:04:16Zen
dc.date.available2015-03-05T11:04:16Zen
dc.date.issued2011-11en
dc.identifier.citationAntibiotic control of tumor-colonizing Salmonella enterica serovar Typhimurium. 2011, 236 (11):1282-90 Exp. Biol. Med. (Maywood)en
dc.identifier.issn1535-3699en
dc.identifier.pmid21987828en
dc.identifier.doi10.1258/ebm.2011.011111en
dc.identifier.urihttp://hdl.handle.net/10033/346200en
dc.description.abstractSystemic administration of Salmonella enterica serovar Typhimurium (S. typhimurium) into tumor-bearing mice results in preferential colonization of tumors and causes shrinkage and sometimes complete tumor clearance. However, in spite of these beneficial antitumor effects, the systemic administration of a bacterial pathogen raises serious safety concerns as well. Addressing those concerns, here, we demonstrate that tumor-colonizing Salmonella can be readily controlled by systemic administration of the antibiotic - ciprofloxacin. Treatment was most effective when started early postinfection. This was achieved at the expense of the efficacy of tumor therapy. In many of the mice treated in such a way, tumors re-grew again. Nevertheless, some mice were able to clear the tumor despite the start of antibiotic treatment only 24 h after the start of infection. Furthermore, we could demonstrate that such mice had elicited a specific antitumor immune response. Thus, S. typhimurium-mediated tumor therapy might be applied safely when combined with early antibiotic treatment. However, the therapeutic power of the bacteria needs to be enhanced in order to provide a more effective therapeutic tool.en
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshAnti-Infective Agentsen
dc.subject.meshCarcinomaen
dc.subject.meshCiprofloxacinen
dc.subject.meshColonic Neoplasmsen
dc.subject.meshDisease Models, Animalen
dc.subject.meshFemaleen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshSalmonella Infectionsen
dc.subject.meshSalmonella typhimuriumen
dc.titleAntibiotic control of tumor-colonizing Salmonella enterica serovar Typhimurium.en
dc.typeArticleen
dc.identifier.journalExperimental biology and medicine (Maywood, N.J.)en

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