2.50
Hdl Handle:
http://hdl.handle.net/10033/36812
Title:
On the Rho'd: the regulation of membrane protrusions by Rho-GTPases.
Authors:
Ladwein, Markus; Rottner, Klemens
Abstract:
Cell migration entails the formation of cellular protrusions such as lamellipodia or filopodia, the growth of which is powered by the polymerisation of actin filaments abutting the plasma membrane. Specific Rho-GTPase subfamilies are able to drive different types of protrusions. However, significant crosstalk between Rho-family members and the interplay of distinct Rho-effectors regulating or modulating actin reorganization in protrusions complicate the picture of how precisely they are initiated and maintained. Here, we briefly sketch our current knowledge on structure and dynamics of different protrusions as well as their regulation by Rho-GTPases. We also comment on topical, unresolved controversies in the field, with special emphasis on the interrelation of different protrusion types, and on the composition of the nanomachineries driving them.
Affiliation:
Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research (HZI), Inhoffen Strasse 7, D-38124 Braunschweig, Germany.
Citation:
On the Rho'd: the regulation of membrane protrusions by Rho-GTPases. 2008, 582 (14):2066-74 FEBS Lett.
Journal:
FEBS letters
Issue Date:
18-Jun-2008
URI:
http://hdl.handle.net/10033/36812
DOI:
10.1016/j.febslet.2008.04.033
PubMed ID:
18442478
Type:
Article
Language:
en
ISSN:
0014-5793
Appears in Collections:
Publications of RG Cytoskeleton Dynamics (CYD)

Full metadata record

DC FieldValue Language
dc.contributor.authorLadwein, Markus-
dc.contributor.authorRottner, Klemens-
dc.date.accessioned2008-08-29T08:49:47Z-
dc.date.available2008-08-29T08:49:47Z-
dc.date.issued2008-06-18-
dc.identifier.citationOn the Rho'd: the regulation of membrane protrusions by Rho-GTPases. 2008, 582 (14):2066-74 FEBS Lett.en
dc.identifier.issn0014-5793-
dc.identifier.pmid18442478-
dc.identifier.doi10.1016/j.febslet.2008.04.033-
dc.identifier.urihttp://hdl.handle.net/10033/36812-
dc.description.abstractCell migration entails the formation of cellular protrusions such as lamellipodia or filopodia, the growth of which is powered by the polymerisation of actin filaments abutting the plasma membrane. Specific Rho-GTPase subfamilies are able to drive different types of protrusions. However, significant crosstalk between Rho-family members and the interplay of distinct Rho-effectors regulating or modulating actin reorganization in protrusions complicate the picture of how precisely they are initiated and maintained. Here, we briefly sketch our current knowledge on structure and dynamics of different protrusions as well as their regulation by Rho-GTPases. We also comment on topical, unresolved controversies in the field, with special emphasis on the interrelation of different protrusion types, and on the composition of the nanomachineries driving them.en
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshCell Movementen
dc.subject.meshMiceen
dc.subject.meshPseudopodiaen
dc.subject.meshrho GTP-Binding Proteinsen
dc.titleOn the Rho'd: the regulation of membrane protrusions by Rho-GTPases.en
dc.typeArticleen
dc.contributor.departmentCytoskeleton Dynamics Group, Helmholtz Centre for Infection Research (HZI), Inhoffen Strasse 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalFEBS lettersen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.