2.50
Hdl Handle:
http://hdl.handle.net/10033/551000
Title:
Sepsis induces specific changes in histone modification patterns in human monocytes.
Authors:
Weiterer, Sebastian; Uhle, Florian; Lichtenstern, Christoph; Siegler, Benedikt H; Bhuju, Sabin; Jarek, Michael; Bartkuhn, Marek; Weigand, Markus A
Abstract:
Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted with a variety of factors, which are integrated within the individual cells and result in changes of their basal state of responsiveness. Epigenetic mechanisms like histone modifications are known to participate in the control of immune reactions, but so far the situation during sepsis is unknown.
Citation:
Sepsis induces specific changes in histone modification patterns in human monocytes. 2015, 10 (3):e0121748 PLoS ONE
Journal:
PloS one
Issue Date:
2015
URI:
http://hdl.handle.net/10033/551000
DOI:
10.1371/journal.pone.0121748
PubMed ID:
25793379
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the research group genomeanalytics (GMAK)

Full metadata record

DC FieldValue Language
dc.contributor.authorWeiterer, Sebastianen
dc.contributor.authorUhle, Florianen
dc.contributor.authorLichtenstern, Christophen
dc.contributor.authorSiegler, Benedikt Hen
dc.contributor.authorBhuju, Sabinen
dc.contributor.authorJarek, Michaelen
dc.contributor.authorBartkuhn, Mareken
dc.contributor.authorWeigand, Markus Aen
dc.date.accessioned2015-04-30T09:27:49Zen
dc.date.available2015-04-30T09:27:49Zen
dc.date.issued2015en
dc.identifier.citationSepsis induces specific changes in histone modification patterns in human monocytes. 2015, 10 (3):e0121748 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid25793379en
dc.identifier.doi10.1371/journal.pone.0121748en
dc.identifier.urihttp://hdl.handle.net/10033/551000en
dc.description.abstractSepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted with a variety of factors, which are integrated within the individual cells and result in changes of their basal state of responsiveness. Epigenetic mechanisms like histone modifications are known to participate in the control of immune reactions, but so far the situation during sepsis is unknown.en
dc.language.isoenen
dc.titleSepsis induces specific changes in histone modification patterns in human monocytes.en
dc.typeArticleen
dc.identifier.journalPloS oneen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.