Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy.

2.50
Hdl Handle:
http://hdl.handle.net/10033/552317
Title:
Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy.
Authors:
Steinmann, Eike; Pietschmann, Thomas
Abstract:
The hepatitis C virus (HCV), a hepatotropic plus-strand RNA virus of the family Flaviviridae, encodes a set of 10 viral proteins. These viral factors act in concert with host proteins to mediate virus entry, and to coordinate RNA replication and virus production. Recent evidence has highlighted the complexity of HCV assembly, which not only involves viral structural proteins but also relies on host factors important for lipoprotein synthesis, and a number of viral assembly co-factors. The latter include the integral membrane protein p7, which oligomerizes and forms cation-selective pores. Based on these properties, p7 was included into the family of viroporins comprising viral proteins from multiple virus families which share the ability to manipulate membrane permeability for ions and to facilitate virus production. Although the precise mechanism as to how p7 and its ion channel function contributes to virus production is still elusive, recent structural and functional studies have revealed a number of intriguing new facets that should guide future efforts to dissect the role and function of p7 in the viral replication cycle. Moreover, a number of small molecules that inhibit production of HCV particles, presumably via interference with p7 function, have been reported. These compounds should not only be instrumental in increasing our understanding of p7 function, but may, in the future, merit further clinical development to ultimately optimize HCV-specific antiviral treatments.
Affiliation:
Division of Experimental Virology, Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Citation:
Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy. 2010, 2 (9):2078-95 Viruses
Journal:
Viruses
Issue Date:
Sep-2010
URI:
http://hdl.handle.net/10033/552317
DOI:
10.3390/v2092078
PubMed ID:
21994720
Type:
Article
Language:
en
ISSN:
1999-4915
Appears in Collections:
publications of the department experimental Virology([TC]EVIR)

Full metadata record

DC FieldValue Language
dc.contributor.authorSteinmann, Eikeen
dc.contributor.authorPietschmann, Thomasen
dc.date.accessioned2015-05-05T13:52:17Zen
dc.date.available2015-05-05T13:52:17Zen
dc.date.issued2010-09en
dc.identifier.citationHepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy. 2010, 2 (9):2078-95 Virusesen
dc.identifier.issn1999-4915en
dc.identifier.pmid21994720en
dc.identifier.doi10.3390/v2092078en
dc.identifier.urihttp://hdl.handle.net/10033/552317en
dc.description.abstractThe hepatitis C virus (HCV), a hepatotropic plus-strand RNA virus of the family Flaviviridae, encodes a set of 10 viral proteins. These viral factors act in concert with host proteins to mediate virus entry, and to coordinate RNA replication and virus production. Recent evidence has highlighted the complexity of HCV assembly, which not only involves viral structural proteins but also relies on host factors important for lipoprotein synthesis, and a number of viral assembly co-factors. The latter include the integral membrane protein p7, which oligomerizes and forms cation-selective pores. Based on these properties, p7 was included into the family of viroporins comprising viral proteins from multiple virus families which share the ability to manipulate membrane permeability for ions and to facilitate virus production. Although the precise mechanism as to how p7 and its ion channel function contributes to virus production is still elusive, recent structural and functional studies have revealed a number of intriguing new facets that should guide future efforts to dissect the role and function of p7 in the viral replication cycle. Moreover, a number of small molecules that inhibit production of HCV particles, presumably via interference with p7 function, have been reported. These compounds should not only be instrumental in increasing our understanding of p7 function, but may, in the future, merit further clinical development to ultimately optimize HCV-specific antiviral treatments.en
dc.language.isoenen
dc.titleHepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy.en
dc.typeArticleen
dc.contributor.departmentDivision of Experimental Virology, Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en
dc.identifier.journalVirusesen

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