Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression.

2.50
Hdl Handle:
http://hdl.handle.net/10033/560873
Title:
Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression.
Authors:
Stentzel, Sebastian; Sundaramoorthy, Nandakumar; Michalik, Stephan; Nordengrün, Maria; Schulz, Sarah; Kolata, Julia; Kloppot, Peggy; Engelmann, Susanne; Steil, Leif; Hecker, Michael; Schmidt, Frank; Völker, Uwe; Roghmann, Mary-Claire; Bröker, Barbara M
Abstract:
Although Staphylococcus aureus is a prominent cause of infections, no vaccine is currently available. Active vaccination relies on immune memory, a core competence of the adaptive immune system. To elucidate whether adaptive immunity can provide protection from serious complications of S. aureus infection, a prospective observational study of 44 patients with S. aureus infection complicated by bacteremia was conducted. At diagnosis, serum IgG binding to S. aureus extracellular proteins was quantified on immunoblots and with Luminex-based FLEXMAP 3D™ assays comprising 64 recombinant S. aureus proteins. Results were correlated with the course of the infection with sepsis as the main outcome variable. S. aureus-specific serum IgG levels at diagnosis of S. aureus infection were lower in patients developing sepsis than in patients without sepsis (P<0.05). The pattern of IgG binding to eight selected S. aureus proteins correctly predicted the disease course in 75% of patients. Robust immune memory of S. aureus was associated with protection from serious complications of bacterial invasion. Serum IgG binding to eight conserved S. aureus proteins enabled stratification of patients with high and low risk of sepsis early in the course of S. aureus infections complicated by bacteremia.
Affiliation:
Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
Citation:
Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression. 2015, 128:1-7 J Proteomics
Journal:
Journal of proteomics
Issue Date:
5-Jul-2015
URI:
http://hdl.handle.net/10033/560873
DOI:
10.1016/j.jprot.2015.06.018
PubMed ID:
26155744
Type:
Article
ISSN:
1876-7737
Appears in Collections:
publications of the research group Microbial Proteomics (MPRO)

Full metadata record

DC FieldValue Language
dc.contributor.authorStentzel, Sebastianen
dc.contributor.authorSundaramoorthy, Nandakumaren
dc.contributor.authorMichalik, Stephanen
dc.contributor.authorNordengrün, Mariaen
dc.contributor.authorSchulz, Sarahen
dc.contributor.authorKolata, Juliaen
dc.contributor.authorKloppot, Peggyen
dc.contributor.authorEngelmann, Susanneen
dc.contributor.authorSteil, Leifen
dc.contributor.authorHecker, Michaelen
dc.contributor.authorSchmidt, Franken
dc.contributor.authorVölker, Uween
dc.contributor.authorRoghmann, Mary-Claireen
dc.contributor.authorBröker, Barbara Men
dc.date.accessioned2015-07-22T13:33:51Zen
dc.date.available2015-07-22T13:33:51Zen
dc.date.issued2015-07-05en
dc.identifier.citationSpecific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression. 2015, 128:1-7 J Proteomicsen
dc.identifier.issn1876-7737en
dc.identifier.pmid26155744en
dc.identifier.doi10.1016/j.jprot.2015.06.018en
dc.identifier.urihttp://hdl.handle.net/10033/560873en
dc.description.abstractAlthough Staphylococcus aureus is a prominent cause of infections, no vaccine is currently available. Active vaccination relies on immune memory, a core competence of the adaptive immune system. To elucidate whether adaptive immunity can provide protection from serious complications of S. aureus infection, a prospective observational study of 44 patients with S. aureus infection complicated by bacteremia was conducted. At diagnosis, serum IgG binding to S. aureus extracellular proteins was quantified on immunoblots and with Luminex-based FLEXMAP 3D™ assays comprising 64 recombinant S. aureus proteins. Results were correlated with the course of the infection with sepsis as the main outcome variable. S. aureus-specific serum IgG levels at diagnosis of S. aureus infection were lower in patients developing sepsis than in patients without sepsis (P<0.05). The pattern of IgG binding to eight selected S. aureus proteins correctly predicted the disease course in 75% of patients. Robust immune memory of S. aureus was associated with protection from serious complications of bacterial invasion. Serum IgG binding to eight conserved S. aureus proteins enabled stratification of patients with high and low risk of sepsis early in the course of S. aureus infections complicated by bacteremia.en
dc.languageENGen
dc.titleSpecific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of proteomicsen

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