Semi-automated nanoprecipitation-system--an option for operator independent, scalable and size adjustable nanoparticle synthesis.

2.50
Hdl Handle:
http://hdl.handle.net/10033/577016
Title:
Semi-automated nanoprecipitation-system--an option for operator independent, scalable and size adjustable nanoparticle synthesis.
Authors:
Rietscher, René; Thum, Carolin; Lehr, Claus-Michael; Schneider, Marc ( 0000-0002-9260-7357 )
Abstract:
The preparation of nano-sized carrier systems increasingly moved into focus of pharmaceutical research and industry in the past decades. Besides the drug load and properties of the selected polymer/lipid, the size of such particles is one of the most important parameters regarding their use as efficient drug delivery systems. However, the preparation of nanoparticles with different sizes in a controlled manner is challenging, especially in terms of reproducibility and scale-up possibility. To overcome these hurdles we developed a system relying on nanoprecipitation, which meets all these requirements of an operator independent, scalable and size-adjustable nanoparticle synthesis-the Semi-Automated Nanoprecipitation-System. This system enables the adaption of the particle size to specific needs based on the process parameters-injection rate, flow rate and polymer concentration-identified within this study. The basic set-up is composed of a syringe pump and a gear pump for a precise control of the flow and injection speed of the system. Furthermore, a home-made tube-straightener guarantees a curvature-free injection point. Thus it could be shown that the production of poly(lactide-co-glycolide) nanoparticles from 150 to 600 nm with a narrow size distribution in a controlled semi-automatic manner is possible.
Affiliation:
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.
Citation:
Semi-automated nanoprecipitation-system--an option for operator independent, scalable and size adjustable nanoparticle synthesis. 2015, 32 (6):1859-63 Pharm. Res.
Journal:
Pharmaceutical research
Issue Date:
Jun-2015
URI:
http://hdl.handle.net/10033/577016
DOI:
10.1007/s11095-014-1612-z
PubMed ID:
25547536
Type:
Article
Language:
en
ISSN:
1573-904X
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorRietscher, Renéen
dc.contributor.authorThum, Carolinen
dc.contributor.authorLehr, Claus-Michaelen
dc.contributor.authorSchneider, Marcen
dc.date.accessioned2015-09-09T13:13:55Zen
dc.date.available2015-09-09T13:13:55Zen
dc.date.issued2015-06en
dc.identifier.citationSemi-automated nanoprecipitation-system--an option for operator independent, scalable and size adjustable nanoparticle synthesis. 2015, 32 (6):1859-63 Pharm. Res.en
dc.identifier.issn1573-904Xen
dc.identifier.pmid25547536en
dc.identifier.doi10.1007/s11095-014-1612-zen
dc.identifier.urihttp://hdl.handle.net/10033/577016en
dc.description.abstractThe preparation of nano-sized carrier systems increasingly moved into focus of pharmaceutical research and industry in the past decades. Besides the drug load and properties of the selected polymer/lipid, the size of such particles is one of the most important parameters regarding their use as efficient drug delivery systems. However, the preparation of nanoparticles with different sizes in a controlled manner is challenging, especially in terms of reproducibility and scale-up possibility. To overcome these hurdles we developed a system relying on nanoprecipitation, which meets all these requirements of an operator independent, scalable and size-adjustable nanoparticle synthesis-the Semi-Automated Nanoprecipitation-System. This system enables the adaption of the particle size to specific needs based on the process parameters-injection rate, flow rate and polymer concentration-identified within this study. The basic set-up is composed of a syringe pump and a gear pump for a precise control of the flow and injection speed of the system. Furthermore, a home-made tube-straightener guarantees a curvature-free injection point. Thus it could be shown that the production of poly(lactide-co-glycolide) nanoparticles from 150 to 600 nm with a narrow size distribution in a controlled semi-automatic manner is possible.en
dc.language.isoenen
dc.titleSemi-automated nanoprecipitation-system--an option for operator independent, scalable and size adjustable nanoparticle synthesis.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.en
dc.identifier.journalPharmaceutical researchen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.