2.50
Hdl Handle:
http://hdl.handle.net/10033/579792
Title:
The antiviral drug ganciclovir does not inhibit microglial proliferation and activation.
Authors:
Skripuletz, Thomas; Salinas Tejedor, Laura; Prajeeth, Chittappen K; Hansmann, Florian; Chhatbar, Chintan; Kucman, Valeria; Zhang, Ning; Raddatz, Barbara B; Detje, Claudia N; Sühs, Kurt-Wolfram; Pul, Refik; Gudi, Viktoria; Kalinke, Ulrich ( 0000-0003-0503-9564 ) ; Baumgärtner, Wolfgang; Stangel, Martin
Abstract:
Ganciclovir is effective in the treatment of human infections with viruses of the Herpesviridae family. Beside antiviral properties, recently ganciclovir was described to inhibit microglial proliferation and disease severity of experimental autoimmune encephalomyelitis, an inflammatory model of multiple sclerosis. Microglial activation and proliferation are main characteristics of neuroinflammatory CNS diseases and inhibition of microglial functions might be beneficial in autoimmune diseases, or detrimental in infectious diseases. The objective of this study was to determine potential inhibitory effects of ganciclovir in three different murine animal models of CNS neuroinflammation in which microglia play an important role: Theiler´s murine encephalomyelitis, the cuprizone model of de- and remyelination, and the vesicular stomatitis virus encephalitis model. In addition, in vitro experiments with microglial cultures were performed to test the hypothesis that ganciclovir inhibits microglial proliferation. In all three animal models, neither microglial proliferation or recruitment nor disease activity was changed by ganciclovir. In vitro experiments confirmed that microglial proliferation was not affected by ganciclovir. In conclusion, our results show that the antiviral drug ganciclovir does not inhibit microglial activation and proliferation in the murine CNS.
Affiliation:
TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen Str. 7, 30625, Hannover, Germany.
Citation:
The antiviral drug ganciclovir does not inhibit microglial proliferation and activation. 2015, 5:14935 Sci Rep
Journal:
Scientific reports
Issue Date:
2015
URI:
http://hdl.handle.net/10033/579792
DOI:
10.1038/srep14935
PubMed ID:
26447351
Type:
Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
publications of the department of experimental infection research ([TC] EXPI)

Full metadata record

DC FieldValue Language
dc.contributor.authorSkripuletz, Thomasen
dc.contributor.authorSalinas Tejedor, Lauraen
dc.contributor.authorPrajeeth, Chittappen Ken
dc.contributor.authorHansmann, Florianen
dc.contributor.authorChhatbar, Chintanen
dc.contributor.authorKucman, Valeriaen
dc.contributor.authorZhang, Ningen
dc.contributor.authorRaddatz, Barbara Ben
dc.contributor.authorDetje, Claudia Nen
dc.contributor.authorSühs, Kurt-Wolframen
dc.contributor.authorPul, Refiken
dc.contributor.authorGudi, Viktoriaen
dc.contributor.authorKalinke, Ulrichen
dc.contributor.authorBaumgärtner, Wolfgangen
dc.contributor.authorStangel, Martinen
dc.date.accessioned2015-10-16T09:57:44Zen
dc.date.available2015-10-16T09:57:44Zen
dc.date.issued2015en
dc.identifier.citationThe antiviral drug ganciclovir does not inhibit microglial proliferation and activation. 2015, 5:14935 Sci Repen
dc.identifier.issn2045-2322en
dc.identifier.pmid26447351en
dc.identifier.doi10.1038/srep14935en
dc.identifier.urihttp://hdl.handle.net/10033/579792en
dc.description.abstractGanciclovir is effective in the treatment of human infections with viruses of the Herpesviridae family. Beside antiviral properties, recently ganciclovir was described to inhibit microglial proliferation and disease severity of experimental autoimmune encephalomyelitis, an inflammatory model of multiple sclerosis. Microglial activation and proliferation are main characteristics of neuroinflammatory CNS diseases and inhibition of microglial functions might be beneficial in autoimmune diseases, or detrimental in infectious diseases. The objective of this study was to determine potential inhibitory effects of ganciclovir in three different murine animal models of CNS neuroinflammation in which microglia play an important role: Theiler´s murine encephalomyelitis, the cuprizone model of de- and remyelination, and the vesicular stomatitis virus encephalitis model. In addition, in vitro experiments with microglial cultures were performed to test the hypothesis that ganciclovir inhibits microglial proliferation. In all three animal models, neither microglial proliferation or recruitment nor disease activity was changed by ganciclovir. In vitro experiments confirmed that microglial proliferation was not affected by ganciclovir. In conclusion, our results show that the antiviral drug ganciclovir does not inhibit microglial activation and proliferation in the murine CNS.en
dc.language.isoenen
dc.titleThe antiviral drug ganciclovir does not inhibit microglial proliferation and activation.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen Str. 7, 30625, Hannover, Germany.en
dc.identifier.journalScientific reportsen

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