2.50
Hdl Handle:
http://hdl.handle.net/10033/594416
Title:
Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa.
Authors:
Dötsch, Andreas; Klawonn, Frank; Jarek, Michael; Scharfe, Maren; Blöcker, Helmut; Häussler, Susanne
Abstract:
The constant increase in development and spread of bacterial resistance to antibiotics poses a serious threat to human health. New sequencing technologies are now on the horizon that will yield massive increases in our capacity for DNA sequencing and will revolutionize the drug discovery process. Since essential genes are promising novel antibiotic targets, the prediction of gene essentiality based on genomic information has become a major focus.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa. 2010, 11:234 BMC Genomics
Journal:
BMC genomics
Issue Date:
2010
URI:
http://hdl.handle.net/10033/594416
DOI:
10.1186/1471-2164-11-234
PubMed ID:
20380691
Type:
Article
Language:
en
ISSN:
1471-2164
Appears in Collections:
publications of the departmentment of molecular bacteriology(MOBA); publications of the departmentment of molecular bacteriology(MOBA)

Full metadata record

DC FieldValue Language
dc.contributor.authorDötsch, Andreasen
dc.contributor.authorKlawonn, Franken
dc.contributor.authorJarek, Michaelen
dc.contributor.authorScharfe, Marenen
dc.contributor.authorBlöcker, Helmuten
dc.contributor.authorHäussler, Susanneen
dc.date.accessioned2016-01-20T14:08:00Zen
dc.date.available2016-01-20T14:08:00Zen
dc.date.issued2010en
dc.identifier.citationEvolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa. 2010, 11:234 BMC Genomicsen
dc.identifier.issn1471-2164en
dc.identifier.pmid20380691en
dc.identifier.doi10.1186/1471-2164-11-234en
dc.identifier.urihttp://hdl.handle.net/10033/594416en
dc.description.abstractThe constant increase in development and spread of bacterial resistance to antibiotics poses a serious threat to human health. New sequencing technologies are now on the horizon that will yield massive increases in our capacity for DNA sequencing and will revolutionize the drug discovery process. Since essential genes are promising novel antibiotic targets, the prediction of gene essentiality based on genomic information has become a major focus.en
dc.language.isoenen
dc.subject.meshEvolution, Molecularen
dc.subject.meshGenes, Bacterialen
dc.subject.meshGenes, Essentialen
dc.subject.meshPseudomonas aeruginosaen
dc.subject.meshSequence Homologyen
dc.titleEvolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalBMC genomicsen

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