2.50
Hdl Handle:
http://hdl.handle.net/10033/595433
Title:
Myxobacteria: natural pharmaceutical factories.
Authors:
Diez, Juana; Martinez, Javier P; Mestres, Jordi; Sasse, Florenz; Frank, Ronald; Meyerhans, Andreas
Abstract:
Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
Myxobacteria: natural pharmaceutical factories. 2012, 11:52 Microb. Cell Fact.
Journal:
Microbial cell factories
Issue Date:
2012
URI:
http://hdl.handle.net/10033/595433
DOI:
10.1186/1475-2859-11-52
PubMed ID:
22545867
Type:
Article
Language:
en
ISSN:
1475-2859
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorDiez, Juanaen
dc.contributor.authorMartinez, Javier Pen
dc.contributor.authorMestres, Jordien
dc.contributor.authorSasse, Florenzen
dc.contributor.authorFrank, Ronalden
dc.contributor.authorMeyerhans, Andreasen
dc.date.accessioned2016-02-02T12:37:58Zen
dc.date.available2016-02-02T12:37:58Zen
dc.date.issued2012en
dc.identifier.citationMyxobacteria: natural pharmaceutical factories. 2012, 11:52 Microb. Cell Fact.en
dc.identifier.issn1475-2859en
dc.identifier.pmid22545867en
dc.identifier.doi10.1186/1475-2859-11-52en
dc.identifier.urihttp://hdl.handle.net/10033/595433en
dc.description.abstractMyxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.en
dc.language.isoenen
dc.relationeu-repo/grantAgreement/EC/FP7/261466en
dc.rightsopenAccessen
dc.subject.meshBiological Productsen
dc.subject.meshDrug Discoveryen
dc.subject.meshMyxococcalesen
dc.subject.meshSpores, Bacterialen
dc.titleMyxobacteria: natural pharmaceutical factories.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalMicrobial cell factoriesen
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