2.50
Hdl Handle:
http://hdl.handle.net/10033/595713
Title:
Interfering with Bacterial Quorum Sensing.
Authors:
Reuter, Kerstin; Steinbach, Anke; Helms, Volkhard
Abstract:
Quorum sensing (QS) describes the exchange of chemical signals in bacterial populations to adjust the bacterial phenotypes according to the density of bacterial cells. This serves to express phenotypes that are advantageous for the group and ensure bacterial survival. To do so, bacterial cells synthesize autoinducer (AI) molecules, release them to the environment, and take them up. Thereby, the AI concentration reflects the cell density. When the AI concentration exceeds a critical threshold in the cells, the AI may activate the expression of virulence-associated genes or of luminescent proteins. It has been argued that targeting the QS system puts less selective pressure on these pathogens and should avoid the development of resistant bacteria. Therefore, the molecular components of QS systems have been suggested as promising targets for developing new anti-infective compounds. Here, we review the QS systems of selected gram-negative and gram-positive bacteria, namely, Vibrio fischeri, Pseudomonas aeruginosa, and Staphylococcus aureus, and discuss various antivirulence strategies based on blocking different components of the QS machinery.
Affiliation:
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.
Citation:
Interfering with Bacterial Quorum Sensing. 2016, 8:1-15 Perspect Medicin Chem
Journal:
Perspectives in medicinal chemistry
Issue Date:
2016
URI:
http://hdl.handle.net/10033/595713
DOI:
10.4137/PMC.S13209
PubMed ID:
26819549
Type:
Article
Language:
en
ISSN:
1177-391X
Appears in Collections:
publications of the department drug design and optimization (HIPS]DDOP)

Full metadata record

DC FieldValue Language
dc.contributor.authorReuter, Kerstinen
dc.contributor.authorSteinbach, Ankeen
dc.contributor.authorHelms, Volkharden
dc.date.accessioned2016-02-05T14:20:00Zen
dc.date.available2016-02-05T14:20:00Zen
dc.date.issued2016en
dc.identifier.citationInterfering with Bacterial Quorum Sensing. 2016, 8:1-15 Perspect Medicin Chemen
dc.identifier.issn1177-391Xen
dc.identifier.pmid26819549en
dc.identifier.doi10.4137/PMC.S13209en
dc.identifier.urihttp://hdl.handle.net/10033/595713en
dc.description.abstractQuorum sensing (QS) describes the exchange of chemical signals in bacterial populations to adjust the bacterial phenotypes according to the density of bacterial cells. This serves to express phenotypes that are advantageous for the group and ensure bacterial survival. To do so, bacterial cells synthesize autoinducer (AI) molecules, release them to the environment, and take them up. Thereby, the AI concentration reflects the cell density. When the AI concentration exceeds a critical threshold in the cells, the AI may activate the expression of virulence-associated genes or of luminescent proteins. It has been argued that targeting the QS system puts less selective pressure on these pathogens and should avoid the development of resistant bacteria. Therefore, the molecular components of QS systems have been suggested as promising targets for developing new anti-infective compounds. Here, we review the QS systems of selected gram-negative and gram-positive bacteria, namely, Vibrio fischeri, Pseudomonas aeruginosa, and Staphylococcus aureus, and discuss various antivirulence strategies based on blocking different components of the QS machinery.en
dc.language.isoenen
dc.titleInterfering with Bacterial Quorum Sensing.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.en
dc.identifier.journalPerspectives in medicinal chemistryen

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