Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles.

2.50
Hdl Handle:
http://hdl.handle.net/10033/595966
Title:
Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles.
Authors:
Guillot, Alexis; Couffin, Anne-Claude; Sejean, Xavier; Navarro, Fabrice; Limberger, Markus; Lehr, Claus-Michael
Abstract:
Contrary to physical characterization techniques for nanopharmaceuticals (shape, size and zeta-potential), the techniques to quantify the free and the entrapped drug remain very few and difficult to transpose in routine analytical laboratories. The application of Solid Phase Extraction (SPE) technique was investigated to overcome this challenge.
Affiliation:
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.
Citation:
Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles. 2015, 32 (12):3999-4009 Pharm. Res.
Journal:
Pharmaceutical research
Issue Date:
Dec-2015
URI:
http://hdl.handle.net/10033/595966
DOI:
10.1007/s11095-015-1761-8
PubMed ID:
26202518
Type:
Article
Language:
en
ISSN:
1573-904X
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorGuillot, Alexisen
dc.contributor.authorCouffin, Anne-Claudeen
dc.contributor.authorSejean, Xavieren
dc.contributor.authorNavarro, Fabriceen
dc.contributor.authorLimberger, Markusen
dc.contributor.authorLehr, Claus-Michaelen
dc.date.accessioned2016-02-09T15:11:50Zen
dc.date.available2016-02-09T15:11:50Zen
dc.date.issued2015-12en
dc.identifier.citationSolid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles. 2015, 32 (12):3999-4009 Pharm. Res.en
dc.identifier.issn1573-904Xen
dc.identifier.pmid26202518en
dc.identifier.doi10.1007/s11095-015-1761-8en
dc.identifier.urihttp://hdl.handle.net/10033/595966en
dc.description.abstractContrary to physical characterization techniques for nanopharmaceuticals (shape, size and zeta-potential), the techniques to quantify the free and the entrapped drug remain very few and difficult to transpose in routine analytical laboratories. The application of Solid Phase Extraction (SPE) technique was investigated to overcome this challenge.en
dc.language.isoenen
dc.titleSolid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.en
dc.identifier.journalPharmaceutical researchen

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