2.50
Hdl Handle:
http://hdl.handle.net/10033/596720
Title:
A strategy for in-silico prediction of skin absorption in man.
Authors:
Selzer, Dominik; Neumann, Dirk; Neumann, Heike; Kostka, Karl-Heinz; Lehr, Claus-Michael; Schaefer, Ulrich F
Abstract:
For some time, in-silico models to address substance transport into and through the skin are gaining more and more importance in different fields of science and industry. In particular, the mathematical prediction of in-vivo skin absorption is of great interest to overcome ethical and economical issues. The presented work outlines a strategy to address this problem and in particular, investigates in-vitro and in-vivo skin penetration experiments of the model compound flufenamic acid solved in an ointment by means of a mathematical model. Experimental stratum corneum concentration-depth profiles (SC-CDP) for various time intervals using two different in-vitro systems (Franz diffusion cell, Saarbruecken penetration model) were examined and simulated with the help of a highly optimized three compartment numerical diffusion model and compared to the findings of SC-CDPs of the in-vivo scenario. Fitted model input parameters (diffusion coefficient and partition coefficient with respect to the stratum corneum) for the in-vitro infinite dose case could be used to predict the in-use conditions in-vitro. Despite apparent differences in calculated partition coefficients between in-vivo and in-vitro studies, prediction of in-vivo scenarios from input parameters calculated from the in-vitro case yielded reasonable results.
Affiliation:
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.
Citation:
A strategy for in-silico prediction of skin absorption in man. 2015, 95 (Pt A):68-76 Eur J Pharm Biopharm
Journal:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
Issue Date:
Sep-2015
URI:
http://hdl.handle.net/10033/596720
DOI:
10.1016/j.ejpb.2015.05.002
PubMed ID:
26022643
Type:
Article
Language:
en
ISSN:
1873-3441
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorSelzer, Dominiken
dc.contributor.authorNeumann, Dirken
dc.contributor.authorNeumann, Heikeen
dc.contributor.authorKostka, Karl-Heinzen
dc.contributor.authorLehr, Claus-Michaelen
dc.contributor.authorSchaefer, Ulrich Fen
dc.date.accessioned2016-02-19T14:20:28Zen
dc.date.available2016-02-19T14:20:28Zen
dc.date.issued2015-09en
dc.identifier.citationA strategy for in-silico prediction of skin absorption in man. 2015, 95 (Pt A):68-76 Eur J Pharm Biopharmen
dc.identifier.issn1873-3441en
dc.identifier.pmid26022643en
dc.identifier.doi10.1016/j.ejpb.2015.05.002en
dc.identifier.urihttp://hdl.handle.net/10033/596720en
dc.description.abstractFor some time, in-silico models to address substance transport into and through the skin are gaining more and more importance in different fields of science and industry. In particular, the mathematical prediction of in-vivo skin absorption is of great interest to overcome ethical and economical issues. The presented work outlines a strategy to address this problem and in particular, investigates in-vitro and in-vivo skin penetration experiments of the model compound flufenamic acid solved in an ointment by means of a mathematical model. Experimental stratum corneum concentration-depth profiles (SC-CDP) for various time intervals using two different in-vitro systems (Franz diffusion cell, Saarbruecken penetration model) were examined and simulated with the help of a highly optimized three compartment numerical diffusion model and compared to the findings of SC-CDPs of the in-vivo scenario. Fitted model input parameters (diffusion coefficient and partition coefficient with respect to the stratum corneum) for the in-vitro infinite dose case could be used to predict the in-use conditions in-vitro. Despite apparent differences in calculated partition coefficients between in-vivo and in-vitro studies, prediction of in-vivo scenarios from input parameters calculated from the in-vitro case yielded reasonable results.en
dc.language.isoenen
dc.titleA strategy for in-silico prediction of skin absorption in man.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.en
dc.identifier.journalEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.Ven

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