Functional modules of sigma factor regulons guarantee adaptability and evolvability.
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Authors
Binder, Sebastian CEckweiler, Denitsa
Schulz, Sebastian
Bielecka, Agata
Nicolai, Tanja
Franke, Raimo
Häussler, Susanne
Müller, A
Issue Date
2016
Metadata
Show full item recordAbstract
The focus of modern molecular biology turns from assigning functions to individual genes towards understanding the expression and regulation of complex sets of molecules. Here, we provide evidence that alternative sigma factor regulons in the pathogen Pseudomonas aeruginosa largely represent insulated functional modules which provide a critical level of biological organization involved in general adaptation and survival processes. Analysis of the operational state of the sigma factor network revealed that transcription factors functionally couple the sigma factor regulons and significantly modulate the transcription levels in the face of challenging environments. The threshold quality of newly evolved transcription factors was reached faster and more robustly in in silico testing when the structural organization of sigma factor networks was taken into account. These results indicate that the modular structures of alternative sigma factor regulons provide P. aeruginosa with a robust framework to function adequately in its environment and at the same time facilitate evolutionary change. Our data support the view that widespread modularity guarantees robustness of biological networks and is a key driver of evolvability.Citation
Functional modules of sigma factor regulons guarantee adaptability and evolvability. 2016, 6:22212 Sci RepAffiliation
Helmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.Journal
Scientific reportsPubMed ID
26915971Type
ArticleLanguage
enISSN
2045-2322ae974a485f413a2113503eed53cd6c53
10.1038/srep22212
Scopus Count
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