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Issue Date
2015
Metadata
Show full item recordAbstract
Many Gram-negative pathogens express a type III secretion (T3SS) system to enable growth and survival within a host. The three human-pathogenic Yersinia species, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica, encode the Ysc T3SS, whose expression is controlled by an AraC-like master regulator called LcrF. In this review, we discuss LcrF structure and function as well as the environmental cues and pathways known to regulate LcrF expression. Similarities and differences in binding motifs and modes of action between LcrF and the Pseudomonas aeruginosa homolog ExsA are summarized. In addition, we present a new bioinformatics analysis that identifies putative LcrF binding sites within Yersinia target gene promoters.Citation
Yersinia Type III Secretion System Master Regulator LcrF. 2015, 198 (4):604-14 J. Bacteriol.Affiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.Journal
Journal of bacteriologyPubMed ID
26644429Type
ArticleLanguage
enISSN
1098-5530ae974a485f413a2113503eed53cd6c53
10.1128/JB.00686-15
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