2.50
Hdl Handle:
http://hdl.handle.net/10033/601589
Title:
Yersinia Type III Secretion System Master Regulator LcrF.
Authors:
Schwiesow, Leah; Lam, Hanh; Dersch, Petra ( 0000-0001-8177-3280 ) ; Auerbuch, Victoria
Abstract:
Many Gram-negative pathogens express a type III secretion (T3SS) system to enable growth and survival within a host. The three human-pathogenic Yersinia species, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica, encode the Ysc T3SS, whose expression is controlled by an AraC-like master regulator called LcrF. In this review, we discuss LcrF structure and function as well as the environmental cues and pathways known to regulate LcrF expression. Similarities and differences in binding motifs and modes of action between LcrF and the Pseudomonas aeruginosa homolog ExsA are summarized. In addition, we present a new bioinformatics analysis that identifies putative LcrF binding sites within Yersinia target gene promoters.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Yersinia Type III Secretion System Master Regulator LcrF. 2015, 198 (4):604-14 J. Bacteriol.
Journal:
Journal of bacteriology
Issue Date:
2015
URI:
http://hdl.handle.net/10033/601589
DOI:
10.1128/JB.00686-15
PubMed ID:
26644429
Type:
Article
Language:
en
ISSN:
1098-5530
Appears in Collections:
publications of the department of molecular Infectionbiology (MIBI)

Full metadata record

DC FieldValue Language
dc.contributor.authorSchwiesow, Leahen
dc.contributor.authorLam, Hanhen
dc.contributor.authorDersch, Petraen
dc.contributor.authorAuerbuch, Victoriaen
dc.date.accessioned2016-03-17T15:47:02Zen
dc.date.available2016-03-17T15:47:02Zen
dc.date.issued2015en
dc.identifier.citationYersinia Type III Secretion System Master Regulator LcrF. 2015, 198 (4):604-14 J. Bacteriol.en
dc.identifier.issn1098-5530en
dc.identifier.pmid26644429en
dc.identifier.doi10.1128/JB.00686-15en
dc.identifier.urihttp://hdl.handle.net/10033/601589en
dc.description.abstractMany Gram-negative pathogens express a type III secretion (T3SS) system to enable growth and survival within a host. The three human-pathogenic Yersinia species, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica, encode the Ysc T3SS, whose expression is controlled by an AraC-like master regulator called LcrF. In this review, we discuss LcrF structure and function as well as the environmental cues and pathways known to regulate LcrF expression. Similarities and differences in binding motifs and modes of action between LcrF and the Pseudomonas aeruginosa homolog ExsA are summarized. In addition, we present a new bioinformatics analysis that identifies putative LcrF binding sites within Yersinia target gene promoters.en
dc.language.isoenen
dc.titleYersinia Type III Secretion System Master Regulator LcrF.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of bacteriologyen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.