2.50
Hdl Handle:
http://hdl.handle.net/10033/609191
Title:
Characterization of Microvesicles Released from Human Red Blood Cells.
Authors:
Nguyen, Duc Bach; Thuy Ly, Thi Bich; Wesseling, Mauro Carlos; Hittinger, Marius; Torge, Afra; Devitt, Andrew; Perrie, Yvonne; Bernhardt, Ingolf
Abstract:
Extracellular vesicles (EVs) are spherical fragments of cell membrane released from various cell types under physiological as well as pathological conditions. Based on their size and origin, EVs are classified as exosome, microvesicles (MVs) and apoptotic bodies. Recently, the release of MVs from human red blood cells (RBCs) under different conditions has been reported. MVs are released by outward budding and fission of the plasma membrane. However, the outward budding process itself, the release of MVs and the physical properties of these MVs have not been well investigated. The aim of this study is to investigate the formation process, isolation and characterization of MVs released from RBCs under conditions of stimulating Ca2+ uptake and activation of protein kinase C.
Affiliation:
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS),Saarland 9 University, 66123 Saarbrücken, Germany.
Citation:
Characterization of Microvesicles Released from Human Red Blood Cells. 2016, 38 (3):1085-99 Cell. Physiol. Biochem.
Journal:
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Issue Date:
2016
URI:
http://hdl.handle.net/10033/609191
DOI:
10.1159/000443059
PubMed ID:
26938586
Type:
Article
Language:
en
ISSN:
1421-9778
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorNguyen, Duc Bachen
dc.contributor.authorThuy Ly, Thi Bichen
dc.contributor.authorWesseling, Mauro Carlosen
dc.contributor.authorHittinger, Mariusen
dc.contributor.authorTorge, Afraen
dc.contributor.authorDevitt, Andrewen
dc.contributor.authorPerrie, Yvonneen
dc.contributor.authorBernhardt, Ingolfen
dc.date.accessioned2016-05-12T14:14:28Zen
dc.date.available2016-05-12T14:14:28Zen
dc.date.issued2016en
dc.identifier.citationCharacterization of Microvesicles Released from Human Red Blood Cells. 2016, 38 (3):1085-99 Cell. Physiol. Biochem.en
dc.identifier.issn1421-9778en
dc.identifier.pmid26938586en
dc.identifier.doi10.1159/000443059en
dc.identifier.urihttp://hdl.handle.net/10033/609191en
dc.description.abstractExtracellular vesicles (EVs) are spherical fragments of cell membrane released from various cell types under physiological as well as pathological conditions. Based on their size and origin, EVs are classified as exosome, microvesicles (MVs) and apoptotic bodies. Recently, the release of MVs from human red blood cells (RBCs) under different conditions has been reported. MVs are released by outward budding and fission of the plasma membrane. However, the outward budding process itself, the release of MVs and the physical properties of these MVs have not been well investigated. The aim of this study is to investigate the formation process, isolation and characterization of MVs released from RBCs under conditions of stimulating Ca2+ uptake and activation of protein kinase C.en
dc.language.isoenen
dc.titleCharacterization of Microvesicles Released from Human Red Blood Cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS),Saarland 9 University, 66123 Saarbrücken, Germany.en
dc.identifier.journalCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyen

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