Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

2.50
Hdl Handle:
http://hdl.handle.net/10033/617325
Title:
Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.
Authors:
Gordon, Sarah; Daneshian, Mardas; Bouwstra, Joke; Caloni, Francesca; Constant, Samuel; Davies, Donna E; Dandekar, Gudrun; Guzman, Carlos A; Fabian, Eric; Haltner, Eleonore; Hartung, Thomas; Hasiwa, Nina; Hayden, Patrick; Kandarova, Helena; Khare, Sangeeta; Krug, Harald F; Kneuer, Carsten; Leist, Marcel; Lian, Guoping; Marx, Uwe; Metzger, Marco; Ott, Katharina; Prieto, Pilar; Roberts, Michael S; Roggen, Erwin L; Tralau, Tewes; van den Braak, Claudia; Walles, Heike; Lehr, Claus-Michael
Abstract:
Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.
Affiliation:
Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1,56123 Saarbrücken, Germany.
Citation:
Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. 2015, 32 (4):327-78 ALTEX
Journal:
ALTEX
Issue Date:
2015
URI:
http://hdl.handle.net/10033/617325
PubMed ID:
26536291
Type:
Article
Language:
en
ISSN:
1868-596X
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorGordon, Sarahen
dc.contributor.authorDaneshian, Mardasen
dc.contributor.authorBouwstra, Jokeen
dc.contributor.authorCaloni, Francescaen
dc.contributor.authorConstant, Samuelen
dc.contributor.authorDavies, Donna Een
dc.contributor.authorDandekar, Gudrunen
dc.contributor.authorGuzman, Carlos Aen
dc.contributor.authorFabian, Ericen
dc.contributor.authorHaltner, Eleonoreen
dc.contributor.authorHartung, Thomasen
dc.contributor.authorHasiwa, Ninaen
dc.contributor.authorHayden, Patricken
dc.contributor.authorKandarova, Helenaen
dc.contributor.authorKhare, Sangeetaen
dc.contributor.authorKrug, Harald Fen
dc.contributor.authorKneuer, Carstenen
dc.contributor.authorLeist, Marcelen
dc.contributor.authorLian, Guopingen
dc.contributor.authorMarx, Uween
dc.contributor.authorMetzger, Marcoen
dc.contributor.authorOtt, Katharinaen
dc.contributor.authorPrieto, Pilaren
dc.contributor.authorRoberts, Michael Sen
dc.contributor.authorRoggen, Erwin Len
dc.contributor.authorTralau, Tewesen
dc.contributor.authorvan den Braak, Claudiaen
dc.contributor.authorWalles, Heikeen
dc.contributor.authorLehr, Claus-Michaelen
dc.date.accessioned2016-07-21T13:21:30Z-
dc.date.available2016-07-21T13:21:30Z-
dc.date.issued2015-
dc.identifier.citationNon-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. 2015, 32 (4):327-78 ALTEXen
dc.identifier.issn1868-596X-
dc.identifier.pmid26536291-
dc.identifier.urihttp://hdl.handle.net/10033/617325-
dc.description.abstractModels of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimal Testing Alternativesen
dc.subject.meshAnimalsen
dc.subject.meshBiomedical Researchen
dc.subject.meshCell Culture Techniquesen
dc.subject.meshEpithelial Cellsen
dc.subject.meshHumansen
dc.subject.meshIntestinesen
dc.subject.meshLungen
dc.subject.meshModels, Animalen
dc.subject.meshPermeabilityen
dc.subject.meshSkinen
dc.subject.meshToxicity Testsen
dc.titleNon-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1,56123 Saarbrücken, Germany.en
dc.identifier.journalALTEXen

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