2.50
Hdl Handle:
http://hdl.handle.net/10033/619939
Title:
Growing tumors induce a local STING dependent Type I IFN response in dendritic cells.
Authors:
Andzinski, Lisa; Spanier, Julia; Kasnitz, Nadine; Kröger, Andrea; Jin, Lei; Brinkmann, Melanie M; Kalinke, Ulrich ( 0000-0003-0503-9564 ) ; Weiss, Siegfried; Jablonska, Jadwiga; Lienenklaus, Stefan
Abstract:
The importance of endogenous Type I IFNs in cancer immune surveillance is well established by now. Their role in polarization of tumor-associated neutrophilic granulocytes into anti-tumor effector cells has been recently demonstrated. Yet, the cellular source of Type I IFNs as well as the mode of induction is not clearly defined. Here, we demonstrate that IFN-β is induced by growing murine tumors. Induction is mainly mediated via STING-dependent signaling pathways, suggesting tumor derived DNA as trigger. Transcription factors IRF3 and IRF5 were activated under these conditions which is consistent with tumor infiltrating dendritic cells (DCs) being the major cellular source of IFN-β at the tumor site. Besides DCs, tumor cells themselves are induced to contribute to the production of IFN-β. Taken together, our data provide further information on immune surveillance by Type I IFNs and suggest novel potent cellular targets for future cancer therapy.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Growing tumors induce a local STING dependent Type I IFN response in dendritic cells. 2016, 139 (6):1350-7 Int. J. Cancer
Journal:
International journal of cancer
Issue Date:
15-Sep-2016
URI:
http://hdl.handle.net/10033/619939
DOI:
10.1002/ijc.30159
PubMed ID:
27116225
Type:
Article
Language:
en
ISSN:
1097-0215
Appears in Collections:
publications of the research group immunity and infection (IMMI)

Full metadata record

DC FieldValue Language
dc.contributor.authorAndzinski, Lisaen
dc.contributor.authorSpanier, Juliaen
dc.contributor.authorKasnitz, Nadineen
dc.contributor.authorKröger, Andreaen
dc.contributor.authorJin, Leien
dc.contributor.authorBrinkmann, Melanie Men
dc.contributor.authorKalinke, Ulrichen
dc.contributor.authorWeiss, Siegfrieden
dc.contributor.authorJablonska, Jadwigaen
dc.contributor.authorLienenklaus, Stefanen
dc.date.accessioned2016-09-07T09:33:33Z-
dc.date.available2016-09-07T09:33:33Z-
dc.date.issued2016-09-15-
dc.identifier.citationGrowing tumors induce a local STING dependent Type I IFN response in dendritic cells. 2016, 139 (6):1350-7 Int. J. Canceren
dc.identifier.issn1097-0215-
dc.identifier.pmid27116225-
dc.identifier.doi10.1002/ijc.30159-
dc.identifier.urihttp://hdl.handle.net/10033/619939-
dc.description.abstractThe importance of endogenous Type I IFNs in cancer immune surveillance is well established by now. Their role in polarization of tumor-associated neutrophilic granulocytes into anti-tumor effector cells has been recently demonstrated. Yet, the cellular source of Type I IFNs as well as the mode of induction is not clearly defined. Here, we demonstrate that IFN-β is induced by growing murine tumors. Induction is mainly mediated via STING-dependent signaling pathways, suggesting tumor derived DNA as trigger. Transcription factors IRF3 and IRF5 were activated under these conditions which is consistent with tumor infiltrating dendritic cells (DCs) being the major cellular source of IFN-β at the tumor site. Besides DCs, tumor cells themselves are induced to contribute to the production of IFN-β. Taken together, our data provide further information on immune surveillance by Type I IFNs and suggest novel potent cellular targets for future cancer therapy.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleGrowing tumors induce a local STING dependent Type I IFN response in dendritic cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalInternational journal of canceren

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