2.50
Hdl Handle:
http://hdl.handle.net/10033/620028
Title:
RNA-based mechanisms of virulence control in Enterobacteriaceae.
Authors:
Heroven, Ann Kathrin; Nuss, Aaron M; Dersch, Petra ( 0000-0001-8177-3280 )
Abstract:
Enteric pathogens of the family Enterobacteriaceae colonize various niches within animals and humans in which they compete with intestinal commensals and are attacked by the host immune system. To survive these hostile environments they possess complex, multilayer regulatory networks that coordinate the control of virulence factors, host-adapted metabolic functions and stress resistance. An important part of these intricate control networks are RNA-based control systems that enable the pathogen to fine-tune its responses. Recent next-generation sequencing approaches revealed a large repertoire of conserved and species-specific riboregulators, including numerous cis- and trans-acting non-coding RNAs, sensory RNA elements (RNA thermometers, riboswitches), regulatory RNA-binding proteins and RNA degrading enzymes which regulate colonization factors, toxins, host defense processes and virulence-relevant physiological and metabolic processes. All of which are important cues for pathogens to sense and respond to fluctuating conditions during the infection. This review covers infection-relevant riboregulators of E. coli, Salmonella, Shigella and Yersinia, highlights their versatile regulatory mechanisms, complex target regulons and functions, and discusses emerging topics and future challenges to fully understand and exploit RNA-based control to combat bacterial infections.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
RNA-based mechanisms of virulence control in Enterobacteriaceae. 2016:1-17 RNA Biol
Journal:
RNA biology
Issue Date:
21-Jul-2016
URI:
http://hdl.handle.net/10033/620028
DOI:
10.1080/15476286.2016.1201617
PubMed ID:
27442607
Type:
Article
ISSN:
1555-8584
Appears in Collections:
publications of the department of molecular Infectionbiology (MIBI)

Full metadata record

DC FieldValue Language
dc.contributor.authorHeroven, Ann Kathrinen
dc.contributor.authorNuss, Aaron Men
dc.contributor.authorDersch, Petraen
dc.date.accessioned2016-09-09T08:31:25Z-
dc.date.available2016-09-09T08:31:25Z-
dc.date.issued2016-07-21-
dc.identifier.citationRNA-based mechanisms of virulence control in Enterobacteriaceae. 2016:1-17 RNA Biolen
dc.identifier.issn1555-8584-
dc.identifier.pmid27442607-
dc.identifier.doi10.1080/15476286.2016.1201617-
dc.identifier.urihttp://hdl.handle.net/10033/620028-
dc.description.abstractEnteric pathogens of the family Enterobacteriaceae colonize various niches within animals and humans in which they compete with intestinal commensals and are attacked by the host immune system. To survive these hostile environments they possess complex, multilayer regulatory networks that coordinate the control of virulence factors, host-adapted metabolic functions and stress resistance. An important part of these intricate control networks are RNA-based control systems that enable the pathogen to fine-tune its responses. Recent next-generation sequencing approaches revealed a large repertoire of conserved and species-specific riboregulators, including numerous cis- and trans-acting non-coding RNAs, sensory RNA elements (RNA thermometers, riboswitches), regulatory RNA-binding proteins and RNA degrading enzymes which regulate colonization factors, toxins, host defense processes and virulence-relevant physiological and metabolic processes. All of which are important cues for pathogens to sense and respond to fluctuating conditions during the infection. This review covers infection-relevant riboregulators of E. coli, Salmonella, Shigella and Yersinia, highlights their versatile regulatory mechanisms, complex target regulons and functions, and discusses emerging topics and future challenges to fully understand and exploit RNA-based control to combat bacterial infections.en
dc.languageENG-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleRNA-based mechanisms of virulence control in Enterobacteriaceae.-
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalRNA biologyen

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