Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620609
Title:
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.
Authors:
Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D; Wölfel, Silke; Gekara, Nelson O; Kröger, Andrea; Överby, Anna K
Abstract:
Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. 2016, 13 (1):277 J Neuroinflammation
Journal:
Journal of neuroinflammation
Issue Date:
24-Oct-2016
URI:
http://hdl.handle.net/10033/620609
DOI:
10.1186/s12974-016-0748-7
PubMed ID:
27776548
Type:
Article
ISSN:
1742-2094
Appears in Collections:
publications of the research group intravital microscopy in infection and immunity (INMI)

Full metadata record

DC FieldValue Language
dc.contributor.authorLindqvist, Richarden
dc.contributor.authorMundt, Filipen
dc.contributor.authorGilthorpe, Jonathan Den
dc.contributor.authorWölfel, Silkeen
dc.contributor.authorGekara, Nelson Oen
dc.contributor.authorKröger, Andreaen
dc.contributor.authorÖverby, Anna Ken
dc.date.accessioned2016-11-30T14:43:27Z-
dc.date.available2016-11-30T14:43:27Z-
dc.date.issued2016-10-24-
dc.identifier.citationFast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. 2016, 13 (1):277 J Neuroinflammationen
dc.identifier.issn1742-2094-
dc.identifier.pmid27776548-
dc.identifier.doi10.1186/s12974-016-0748-7-
dc.identifier.urihttp://hdl.handle.net/10033/620609-
dc.description.abstractNeurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined.en
dc.languageENG-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleFast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.-
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of neuroinflammationen

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