Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620624
Title:
Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs.
Authors:
Siddharta, Anindya; Pfaender, Stephanie; Malassa, Angelina; Doerrbecker, Juliane; Anggakusuma; Engelmann, Michael; Nugraha, Boya; Steinmann, Joerg; Todt, Daniel; Vondran, Florian W R; Mateu-Gelabert, Pedro; Goffinet, Christine; Steinmann, Eike
Abstract:
Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.
Citation:
Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. 2016, 6:36619 Sci Rep
Journal:
Scientific reports
Issue Date:
18-Nov-2016
URI:
http://hdl.handle.net/10033/620624
DOI:
10.1038/srep36619
PubMed ID:
27857152
Type:
Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
publications of the research group virus transmission ([TC]VIRT)

Full metadata record

DC FieldValue Language
dc.contributor.authorSiddharta, Anindyaen
dc.contributor.authorPfaender, Stephanieen
dc.contributor.authorMalassa, Angelinaen
dc.contributor.authorDoerrbecker, Julianeen
dc.contributor.authorAnggakusumaen
dc.contributor.authorEngelmann, Michaelen
dc.contributor.authorNugraha, Boyaen
dc.contributor.authorSteinmann, Joergen
dc.contributor.authorTodt, Danielen
dc.contributor.authorVondran, Florian W Ren
dc.contributor.authorMateu-Gelabert, Pedroen
dc.contributor.authorGoffinet, Christineen
dc.contributor.authorSteinmann, Eikeen
dc.date.accessioned2016-12-05T15:14:17Z-
dc.date.available2016-12-05T15:14:17Z-
dc.date.issued2016-11-18-
dc.identifier.citationInactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. 2016, 6:36619 Sci Repen
dc.identifier.issn2045-2322-
dc.identifier.pmid27857152-
dc.identifier.doi10.1038/srep36619-
dc.identifier.urihttp://hdl.handle.net/10033/620624-
dc.description.abstractHepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleInactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs.en
dc.typeArticleen
dc.identifier.journalScientific reportsen

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