2.50
Hdl Handle:
http://hdl.handle.net/10033/620741
Title:
Peptide-mediated interference with influenza A virus polymerase.
Authors:
Ghanem, Alexander; Mayer, Daniel; Chase, Geoffrey; Tegge, Werner; Frank, Ronald; Kochs, Georg; García-Sastre, Adolfo; Schwemmle, Martin
Abstract:
The assembly of the polymerase complex of influenza A virus from the three viral polymerase subunits PB1, PB2, and PA is required for viral RNA synthesis. We show that peptides which specifically bind to the protein-protein interaction domains in the subunits responsible for complex formation interfere with polymerase complex assembly and inhibit viral replication. Specifically, we provide evidence that a 25-amino-acid peptide corresponding to the PA-binding domain of PB1 blocks the polymerase activity of influenza A virus and inhibits viral spread. Targeting polymerase subunit interactions therefore provides a novel strategy to develop antiviral compounds against influenza A virus or other viruses.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Peptide-mediated interference with influenza A virus polymerase. 2007, 81 (14):7801-4 J. Virol.
Journal:
Journal of virology
Issue Date:
Jul-2007
URI:
http://hdl.handle.net/10033/620741
DOI:
10.1128/JVI.00724-07
PubMed ID:
17494067
Type:
Article
Language:
en
ISSN:
0022-538X
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorGhanem, Alexanderen
dc.contributor.authorMayer, Danielen
dc.contributor.authorChase, Geoffreyen
dc.contributor.authorTegge, Werneren
dc.contributor.authorFrank, Ronalden
dc.contributor.authorKochs, Georgen
dc.contributor.authorGarcía-Sastre, Adolfoen
dc.contributor.authorSchwemmle, Martinen
dc.date.accessioned2017-01-24T10:25:18Z-
dc.date.available2017-01-24T10:25:18Z-
dc.date.issued2007-07-
dc.identifier.citationPeptide-mediated interference with influenza A virus polymerase. 2007, 81 (14):7801-4 J. Virol.en
dc.identifier.issn0022-538X-
dc.identifier.pmid17494067-
dc.identifier.doi10.1128/JVI.00724-07-
dc.identifier.urihttp://hdl.handle.net/10033/620741-
dc.description.abstractThe assembly of the polymerase complex of influenza A virus from the three viral polymerase subunits PB1, PB2, and PA is required for viral RNA synthesis. We show that peptides which specifically bind to the protein-protein interaction domains in the subunits responsible for complex formation interfere with polymerase complex assembly and inhibit viral replication. Specifically, we provide evidence that a 25-amino-acid peptide corresponding to the PA-binding domain of PB1 blocks the polymerase activity of influenza A virus and inhibits viral spread. Targeting polymerase subunit interactions therefore provides a novel strategy to develop antiviral compounds against influenza A virus or other viruses.en
dc.language.isoenen
dc.subject.meshAmino Acid Sequenceen
dc.subject.meshDNA-Directed RNA Polymerasesen
dc.subject.meshInfluenza A virusen
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshPeptidesen
dc.subject.meshVirus Replicationen
dc.titlePeptide-mediated interference with influenza A virus polymerase.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of virologyen

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