Metabolic pathways in T cell activation and lineage differentiation.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620750
Title:
Metabolic pathways in T cell activation and lineage differentiation.
Authors:
Almeida, Luís; Lochner, Matthias; Berod, Luciana; Sparwasser, Tim ( 0000-0001-5645-902X )
Abstract:
Recent advances in the field of immunometabolism support the concept that fundamental processes in T cell biology, such as TCR-mediated activation and T helper lineage differentiation, are closely linked to changes in the cellular metabolic programs. Although the major task of the intermediate metabolism is to provide the cell with a constant supply of energy and molecular precursors for the production of biomolecules, the dynamic regulation of metabolic pathways also plays an active role in shaping T cell responses. Key metabolic processes such as glycolysis, fatty acid and mitochondrial metabolism are now recognized as crucial players in T cell activation and differentiation, and their modulation can differentially affect the development of T helper cell lineages. In this review, we describe the diverse metabolic processes that T cells engage during their life cycle from naïve towards effector and memory T cells. We consider in particular how the cellular metabolism may actively support the function of T cells in their different states. Moreover, we discuss how molecular regulators such as mTOR or AMPK link environmental changes to adaptations in the cellular metabolism and elucidate the consequences on T cell differentiation and function.
Affiliation:
TwinCore, Centre for experimental and clinical infection research GmbH, Ferodor-Lynen-Str.7,30625 Hannover, Germany.
Citation:
Metabolic pathways in T cell activation and lineage differentiation. 2016, 28 (5):514-524 Semin. Immunol.
Journal:
Seminars in immunology
Issue Date:
Oct-2016
URI:
http://hdl.handle.net/10033/620750
DOI:
10.1016/j.smim.2016.10.009
PubMed ID:
27825556
Type:
Article
Language:
en
ISSN:
1096-3618
Appears in Collections:
publications of the TwinCore unit Infection immunology

Full metadata record

DC FieldValue Language
dc.contributor.authorAlmeida, Luísen
dc.contributor.authorLochner, Matthiasen
dc.contributor.authorBerod, Lucianaen
dc.contributor.authorSparwasser, Timen
dc.date.accessioned2017-01-26T14:14:40Z-
dc.date.available2017-01-26T14:14:40Z-
dc.date.issued2016-10-
dc.identifier.citationMetabolic pathways in T cell activation and lineage differentiation. 2016, 28 (5):514-524 Semin. Immunol.en
dc.identifier.issn1096-3618-
dc.identifier.pmid27825556-
dc.identifier.doi10.1016/j.smim.2016.10.009-
dc.identifier.urihttp://hdl.handle.net/10033/620750-
dc.description.abstractRecent advances in the field of immunometabolism support the concept that fundamental processes in T cell biology, such as TCR-mediated activation and T helper lineage differentiation, are closely linked to changes in the cellular metabolic programs. Although the major task of the intermediate metabolism is to provide the cell with a constant supply of energy and molecular precursors for the production of biomolecules, the dynamic regulation of metabolic pathways also plays an active role in shaping T cell responses. Key metabolic processes such as glycolysis, fatty acid and mitochondrial metabolism are now recognized as crucial players in T cell activation and differentiation, and their modulation can differentially affect the development of T helper cell lineages. In this review, we describe the diverse metabolic processes that T cells engage during their life cycle from naïve towards effector and memory T cells. We consider in particular how the cellular metabolism may actively support the function of T cells in their different states. Moreover, we discuss how molecular regulators such as mTOR or AMPK link environmental changes to adaptations in the cellular metabolism and elucidate the consequences on T cell differentiation and function.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMetabolic pathways in T cell activation and lineage differentiation.en
dc.typeArticleen
dc.contributor.departmentTwinCore, Centre for experimental and clinical infection research GmbH, Ferodor-Lynen-Str.7,30625 Hannover, Germany.en
dc.identifier.journalSeminars in immunologyen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.