2.50
Hdl Handle:
http://hdl.handle.net/10033/620804
Title:
In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome.
Authors:
Todt, Daniel; Gisa, Anett; Radonic, Aleksandar; Nitsche, Andreas; Behrendt, Patrick; Suneetha, Pothakamuri Venkata; Pischke, Sven; Bremer, Birgit; Brown, Richard J P; Manns, Michael P; Cornberg, Markus; Bock, C Thomas; Steinmann, Eike; Wedemeyer, Heiner
Abstract:
Hepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. Ribavirin (RBV) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the appearance of a distinct HEV polymerase mutant (G1634R). Here, we performed a detailed analysis of HEV viral intrahost evolution during chronic hepatitis E infections.
Affiliation:
Twincore Centre of Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany.
Citation:
In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. 2016, 65 (10):1733-43 Gut
Journal:
Gut
Issue Date:
Oct-2016
URI:
http://hdl.handle.net/10033/620804
DOI:
10.1136/gutjnl-2015-311000
PubMed ID:
27222534
Type:
Article
Language:
en
ISSN:
1468-3288
Appears in Collections:
publications of the research group virus transmission ([TC]VIRT)

Full metadata record

DC FieldValue Language
dc.contributor.authorTodt, Danielen
dc.contributor.authorGisa, Anetten
dc.contributor.authorRadonic, Aleksandaren
dc.contributor.authorNitsche, Andreasen
dc.contributor.authorBehrendt, Patricken
dc.contributor.authorSuneetha, Pothakamuri Venkataen
dc.contributor.authorPischke, Svenen
dc.contributor.authorBremer, Birgiten
dc.contributor.authorBrown, Richard J Pen
dc.contributor.authorManns, Michael Pen
dc.contributor.authorCornberg, Markusen
dc.contributor.authorBock, C Thomasen
dc.contributor.authorSteinmann, Eikeen
dc.contributor.authorWedemeyer, Heineren
dc.date.accessioned2017-02-03T09:50:39Z-
dc.date.available2017-02-03T09:50:39Z-
dc.date.issued2016-10-
dc.identifier.citationIn vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. 2016, 65 (10):1733-43 Guten
dc.identifier.issn1468-3288-
dc.identifier.pmid27222534-
dc.identifier.doi10.1136/gutjnl-2015-311000-
dc.identifier.urihttp://hdl.handle.net/10033/620804-
dc.description.abstractHepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. Ribavirin (RBV) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the appearance of a distinct HEV polymerase mutant (G1634R). Here, we performed a detailed analysis of HEV viral intrahost evolution during chronic hepatitis E infections.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleIn vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome.en
dc.typeArticleen
dc.contributor.departmentTwincore Centre of Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany.en
dc.identifier.journalGuten

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