Immune modulator adamantylamide dipeptide stimulates efficient major histocompatibility complex class I-restricted responses in mice.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620817
Title:
Immune modulator adamantylamide dipeptide stimulates efficient major histocompatibility complex class I-restricted responses in mice.
Authors:
Becker, Pablo D; Nörder, Miriam; Guzmán, Carlos Alberto; Grinstein, Saul
Abstract:
Adamantylamide L-alanyl-D-isoglutamine (AdDP) is a synthetic adjuvant which belongs to the family of the desmuramyl peptides. AdDP exerts its adjuvant properties when it is administered either by the parenteral or by the mucosal route, leading to the elicitation of strong humoral responses at both the systemic and the mucosal levels. However, very little is known about the effect of AdDP on cellular immunity. Here we demonstrate that AdDP is able to stimulate cellular responses, which are characterized by the release of gamma interferon by CD8+ T cells when they are restimulated with a major histocompatibility complex class I-restricted peptide and strong in vivo lymphocyte-mediated cytotoxic activity. The capacity of AdDP to stimulate the elicitation of both cellular and humoral adaptive responses makes this adjuvant a promising tool for the development of mucosal vaccine formulations.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Immune modulator adamantylamide dipeptide stimulates efficient major histocompatibility complex class I-restricted responses in mice. 2007, 14 (5):538-43 Clin. Vaccine Immunol.
Journal:
Clinical and vaccine immunology : CVI
Issue Date:
May-2007
URI:
http://hdl.handle.net/10033/620817
DOI:
10.1128/CVI.00316-06
PubMed ID:
17344349
Type:
Article
Language:
en
ISSN:
1556-6811
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorBecker, Pablo Den
dc.contributor.authorNörder, Miriamen
dc.contributor.authorGuzmán, Carlos Albertoen
dc.contributor.authorGrinstein, Saulen
dc.date.accessioned2017-02-15T12:06:41Z-
dc.date.available2017-02-15T12:06:41Z-
dc.date.issued2007-05-
dc.identifier.citationImmune modulator adamantylamide dipeptide stimulates efficient major histocompatibility complex class I-restricted responses in mice. 2007, 14 (5):538-43 Clin. Vaccine Immunol.en
dc.identifier.issn1556-6811-
dc.identifier.pmid17344349-
dc.identifier.doi10.1128/CVI.00316-06-
dc.identifier.urihttp://hdl.handle.net/10033/620817-
dc.description.abstractAdamantylamide L-alanyl-D-isoglutamine (AdDP) is a synthetic adjuvant which belongs to the family of the desmuramyl peptides. AdDP exerts its adjuvant properties when it is administered either by the parenteral or by the mucosal route, leading to the elicitation of strong humoral responses at both the systemic and the mucosal levels. However, very little is known about the effect of AdDP on cellular immunity. Here we demonstrate that AdDP is able to stimulate cellular responses, which are characterized by the release of gamma interferon by CD8+ T cells when they are restimulated with a major histocompatibility complex class I-restricted peptide and strong in vivo lymphocyte-mediated cytotoxic activity. The capacity of AdDP to stimulate the elicitation of both cellular and humoral adaptive responses makes this adjuvant a promising tool for the development of mucosal vaccine formulations.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdjuvants, Immunologicen
dc.subject.meshAmantadineen
dc.subject.meshAnimalsen
dc.subject.meshAntibody Formationen
dc.subject.meshAntigens, Bacterialen
dc.subject.meshCD8-Positive T-Lymphocytesen
dc.subject.meshDipeptidesen
dc.subject.meshFemaleen
dc.subject.meshGenes, MHC Class Ien
dc.subject.meshImmunity, Cellularen
dc.subject.meshImmunizationen
dc.subject.meshInterferon-gammaen
dc.subject.meshMajor Histocompatibility Complexen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshMice, Inbred C57BLen
dc.titleImmune modulator adamantylamide dipeptide stimulates efficient major histocompatibility complex class I-restricted responses in mice.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalClinical and vaccine immunology : CVIen
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