Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620819
Title:
Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection.
Authors:
Bahgat, Mahmoud M; Błazejewska, Paulina; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
Host serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection. 2011, 8:27 Virol. J.
Journal:
Virology journal
Issue Date:
20-Jan-2011
URI:
http://hdl.handle.net/10033/620819
DOI:
10.1186/1743-422X-8-27
PubMed ID:
21251300
Type:
Article
Language:
en
ISSN:
1743-422X
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorBahgat, Mahmoud Men
dc.contributor.authorBłazejewska, Paulinaen
dc.contributor.authorSchughart, Klausen
dc.date.accessioned2017-02-15T12:47:51Z-
dc.date.available2017-02-15T12:47:51Z-
dc.date.issued2011-01-20-
dc.identifier.citationInhibition of lung serine proteases in mice: a potentially new approach to control influenza infection. 2011, 8:27 Virol. J.en
dc.identifier.issn1743-422X-
dc.identifier.pmid21251300-
dc.identifier.doi10.1186/1743-422X-8-27-
dc.identifier.urihttp://hdl.handle.net/10033/620819-
dc.description.abstractHost serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshBody Weighten
dc.subject.meshCell Lineen
dc.subject.meshEpithelial Cellsen
dc.subject.meshHumansen
dc.subject.meshInfluenza A Virus, H1N1 Subtypeen
dc.subject.meshInfluenza A Virus, H7N7 Subtypeen
dc.subject.meshLungen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshMice, Inbred DBAen
dc.subject.meshOrthomyxoviridae Infectionsen
dc.subject.meshSerine Proteasesen
dc.subject.meshSerine Proteinase Inhibitorsen
dc.subject.meshVirus Replicationen
dc.titleInhibition of lung serine proteases in mice: a potentially new approach to control influenza infection.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalVirology journalen

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