Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620838
Title:
Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection.
Authors:
Thänert, Robert; Goldmann, Oliver; Beineke, Andreas; Medina, Eva
Abstract:
The rise of antibiotic resistance calls for alternative strategies to treat bacterial infections. One attractive strategy is to directly target bacterial virulence factors with anti-virulence drugs. The expression of virulence traits by pathogens is, however, not constitutive but rather induced by the level of stress encountered within the host. Here we use dual RNA sequencing (RNA-seq) to show that intrinsic variability in the level of host resistance greatly affects the pathogen's transcriptome in vivo. Through analysis of the transcriptional profiles of host and pathogen during Staphylococcus aureus infection of two mouse strains, shown to be susceptible (A/J) or resistant (C57BL/6) to the pathogen, we demonstrate that the expression of virulence factors is dependent on the encountered host resistance. We furthermore provide evidence that this dependence strongly influences the efficacy of anti-virulence strategies, highlighting a potential limitation for the implementation of these strategies.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection. 2017, 8:14268 Nat Commun
Journal:
Nature communications
Issue Date:
3-Feb-2017
URI:
http://hdl.handle.net/10033/620838
DOI:
10.1038/ncomms14268
PubMed ID:
28155859
Type:
Article
Language:
en
ISSN:
2041-1723
Appears in Collections:
publications of the research group immunology of infection (INI)

Full metadata record

DC FieldValue Language
dc.contributor.authorThänert, Roberten
dc.contributor.authorGoldmann, Oliveren
dc.contributor.authorBeineke, Andreasen
dc.contributor.authorMedina, Evaen
dc.date.accessioned2017-02-22T15:41:29Z-
dc.date.available2017-02-22T15:41:29Z-
dc.date.issued2017-02-03-
dc.identifier.citationHost-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection. 2017, 8:14268 Nat Communen
dc.identifier.issn2041-1723-
dc.identifier.pmid28155859-
dc.identifier.doi10.1038/ncomms14268-
dc.identifier.urihttp://hdl.handle.net/10033/620838-
dc.description.abstractThe rise of antibiotic resistance calls for alternative strategies to treat bacterial infections. One attractive strategy is to directly target bacterial virulence factors with anti-virulence drugs. The expression of virulence traits by pathogens is, however, not constitutive but rather induced by the level of stress encountered within the host. Here we use dual RNA sequencing (RNA-seq) to show that intrinsic variability in the level of host resistance greatly affects the pathogen's transcriptome in vivo. Through analysis of the transcriptional profiles of host and pathogen during Staphylococcus aureus infection of two mouse strains, shown to be susceptible (A/J) or resistant (C57BL/6) to the pathogen, we demonstrate that the expression of virulence factors is dependent on the encountered host resistance. We furthermore provide evidence that this dependence strongly influences the efficacy of anti-virulence strategies, highlighting a potential limitation for the implementation of these strategies.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleHost-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalNature communicationsen
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