Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620839
Title:
Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence.
Authors:
Effenberger-Neidnicht, Katharina; Breyer, Sandra; Mahal, Katharina; Sasse, Florenz; Schobert, Rainer
Abstract:
Doxorubicin (1) is commonly used in the treatment of a wide range of cancers. Some N-acylhydrazones of 1 were previously found to have an improved tumour and organ selectivity. In order to clarify the molecular basis for this effect, the cellular uptake into various cancer cells and the localisation in PtK(2) potoroo kidney cells of 1 and its N-acylhydrazones derived from heptadecanoic acid (2) and 11-(menthoxycarbonyl)undecanoic acid (3) were studied drawing on their intrinsic fluorescence.
Citation:
Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence. 2012, 69 (1):85-90 Cancer Chemother. Pharmacol.
Journal:
Cancer chemotherapy and pharmacology
Issue Date:
Jan-2012
URI:
http://hdl.handle.net/10033/620839
DOI:
10.1007/s00280-011-1675-z
PubMed ID:
21607555
Type:
Article
Language:
en
ISSN:
1432-0843
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorEffenberger-Neidnicht, Katharinaen
dc.contributor.authorBreyer, Sandraen
dc.contributor.authorMahal, Katharinaen
dc.contributor.authorSasse, Florenzen
dc.contributor.authorSchobert, Raineren
dc.date.accessioned2017-02-23T10:29:00Z-
dc.date.available2017-02-23T10:29:00Z-
dc.date.issued2012-01-
dc.identifier.citationModification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence. 2012, 69 (1):85-90 Cancer Chemother. Pharmacol.en
dc.identifier.issn1432-0843-
dc.identifier.pmid21607555-
dc.identifier.doi10.1007/s00280-011-1675-z-
dc.identifier.urihttp://hdl.handle.net/10033/620839-
dc.description.abstractDoxorubicin (1) is commonly used in the treatment of a wide range of cancers. Some N-acylhydrazones of 1 were previously found to have an improved tumour and organ selectivity. In order to clarify the molecular basis for this effect, the cellular uptake into various cancer cells and the localisation in PtK(2) potoroo kidney cells of 1 and its N-acylhydrazones derived from heptadecanoic acid (2) and 11-(menthoxycarbonyl)undecanoic acid (3) were studied drawing on their intrinsic fluorescence.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshAntibiotics, Antineoplasticen
dc.subject.meshCell Line, Tumoren
dc.subject.meshCell Membraneen
dc.subject.meshCells, Cultureden
dc.subject.meshDoxorubicinen
dc.subject.meshDrug Resistance, Multipleen
dc.subject.meshDrug Resistance, Neoplasmen
dc.subject.meshEpithelial Cellsen
dc.subject.meshFemaleen
dc.subject.meshFluorometryen
dc.subject.meshHumansen
dc.subject.meshHydrazonesen
dc.subject.meshKidneyen
dc.subject.meshLysosomesen
dc.subject.meshMaleen
dc.subject.meshMicroscopy, Fluorescenceen
dc.subject.meshNeoplasmsen
dc.subject.meshPotoroidaeen
dc.subject.meshTime Factorsen
dc.titleModification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence.en
dc.typeArticleen
dc.identifier.journalCancer chemotherapy and pharmacologyen
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