2.50
Hdl Handle:
http://hdl.handle.net/10033/620843
Title:
Sustained viral load and late death in Rag2-/- mice after influenza A virus infection
Authors:
Wu, Haiya; Haist, Verena; Baumgärtner, Wolfgang; Schughart, Klaus
Abstract:
Abstract The importance of the adaptive immune response for secondary influenza infections and protection from a lethal challenge after vaccination has been well documented. However, some controversy still exists concerning the specific involvement of B and T cells during a primary infection. Here, we have followed the survival, weight loss, viral load and lung pathology in Rag2 -/- knock-out mice after infection with influenza A virus (H1N1). Infected wild type mice initially lost weight early after infection but then cleared the virus and recovered. Rag2 -/- mice, however, showed similar weight loss kinetics in the early stages after infection but weight loss continued post infection and culminated in death. In contrast to wild type mice, Rag2 -/- mice were not able to clear the virus, despite an increased inflammatory response. Furthermore, they did not recruit virus-specific lymphocytes into the lung in the later stages after infection and exhibited sustained pulmonary lesions.
Affiliation:
Helmholtz Centre for infection research, Ihoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Virology Journal. 2010 Jul 28;7(1):172
Issue Date:
28-Jul-2010
URI:
http://dx.doi.org/10.1186/1743-422X-7-172; http://hdl.handle.net/10033/620843
Type:
Article
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorWu, Haiyaen
dc.contributor.authorHaist, Verenaen
dc.contributor.authorBaumgärtner, Wolfgangen
dc.contributor.authorSchughart, Klausen
dc.date.accessioned2017-03-06T11:35:28Z-
dc.date.available2017-03-06T11:35:28Z-
dc.date.issued2010-07-28-
dc.identifier.citationVirology Journal. 2010 Jul 28;7(1):172en
dc.identifier.urihttp://dx.doi.org/10.1186/1743-422X-7-172-
dc.identifier.urihttp://hdl.handle.net/10033/620843-
dc.description.abstractAbstract The importance of the adaptive immune response for secondary influenza infections and protection from a lethal challenge after vaccination has been well documented. However, some controversy still exists concerning the specific involvement of B and T cells during a primary infection. Here, we have followed the survival, weight loss, viral load and lung pathology in Rag2 -/- knock-out mice after infection with influenza A virus (H1N1). Infected wild type mice initially lost weight early after infection but then cleared the virus and recovered. Rag2 -/- mice, however, showed similar weight loss kinetics in the early stages after infection but weight loss continued post infection and culminated in death. In contrast to wild type mice, Rag2 -/- mice were not able to clear the virus, despite an increased inflammatory response. Furthermore, they did not recruit virus-specific lymphocytes into the lung in the later stages after infection and exhibited sustained pulmonary lesions.en
dc.titleSustained viral load and late death in Rag2-/- mice after influenza A virus infection-
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Ihoffenstr. 7, 38124 Braunschweig, Germany.en
dc.language.rfc3066enen
dc.rights.holderWu et al.en
dc.date.updated2015-09-04T08:26:33Zen
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