Minutellins A - D, azaphilones from the stromata of Annulohypoxylon minutellum (Xylariaceae).

2.50
Hdl Handle:
http://hdl.handle.net/10033/620867
Title:
Minutellins A - D, azaphilones from the stromata of Annulohypoxylon minutellum (Xylariaceae).
Authors:
Kuhnert, Eric; Surup, Frank; Halecker, Sandra; Stadler, Marc ( 0000-0002-7284-8671 )
Abstract:
During the course of our screening for new metabolites with chemotaxonomic importance from stromata of fungi from the family Xylariaceae, we characterized several interesting metabolites in the fungus Annulohypoxylon minutellum. Extraction of the fruiting bodies and purification by preparative HPLC resulted in the isolation of five metabolites. The main compound was identified as the known metabolite hinnulin A (5), while four minor compounds were found to represent previously undescribed azaphilones, named minutellins A - D (1-4). Their planar structures were elucidated using NMR and HRESIMS data; absolute stereochemistry was assigned by CD data and Mosher's method. Compounds 1, 3 and 5 showed cytotoxic effects against murine and human cells. As the production of 1-5 is restricted to a group of closely related Annulohypoxylon species, they serve well as chemotaxonomic marker.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Minutellins A - D, azaphilones from the stromata of Annulohypoxylon minutellum (Xylariaceae). 2017 Phytochemistry
Journal:
Phytochemistry
Issue Date:
16-Feb-2017
URI:
http://hdl.handle.net/10033/620867
DOI:
10.1016/j.phytochem.2017.02.014
PubMed ID:
28215421
Type:
Article
Language:
en
ISSN:
1873-3700
Appears in Collections:
publications of the department of microbial drugs (MWIS)

Full metadata record

DC FieldValue Language
dc.contributor.authorKuhnert, Ericen
dc.contributor.authorSurup, Franken
dc.contributor.authorHalecker, Sandraen
dc.contributor.authorStadler, Marcen
dc.date.accessioned2017-03-23T08:40:41Z-
dc.date.available2017-03-23T08:40:41Z-
dc.date.issued2017-02-16-
dc.identifier.citationMinutellins A - D, azaphilones from the stromata of Annulohypoxylon minutellum (Xylariaceae). 2017 Phytochemistryen
dc.identifier.issn1873-3700-
dc.identifier.pmid28215421-
dc.identifier.doi10.1016/j.phytochem.2017.02.014-
dc.identifier.urihttp://hdl.handle.net/10033/620867-
dc.description.abstractDuring the course of our screening for new metabolites with chemotaxonomic importance from stromata of fungi from the family Xylariaceae, we characterized several interesting metabolites in the fungus Annulohypoxylon minutellum. Extraction of the fruiting bodies and purification by preparative HPLC resulted in the isolation of five metabolites. The main compound was identified as the known metabolite hinnulin A (5), while four minor compounds were found to represent previously undescribed azaphilones, named minutellins A - D (1-4). Their planar structures were elucidated using NMR and HRESIMS data; absolute stereochemistry was assigned by CD data and Mosher's method. Compounds 1, 3 and 5 showed cytotoxic effects against murine and human cells. As the production of 1-5 is restricted to a group of closely related Annulohypoxylon species, they serve well as chemotaxonomic marker.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMinutellins A - D, azaphilones from the stromata of Annulohypoxylon minutellum (Xylariaceae).en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalPhytochemistryen

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