2.50
Hdl Handle:
http://hdl.handle.net/10033/620878
Title:
RNA Regulators: Formidable Modulators of Yersinia Virulence.
Authors:
Nuss, Aaron M; Heroven, Ann Kathrin; Dersch, Petra ( 0000-0001-8177-3280 )
Abstract:
A large repertoire of RNA-based regulatory mechanisms, including a plethora of cis- and trans-acting noncoding RNAs (ncRNAs), sensory RNA elements, regulatory RNA-binding proteins, and RNA-degrading enzymes have been uncovered lately as key players in the regulation of metabolism, stress responses, and virulence of the genus Yersinia. Many of them are strictly controlled in response to fluctuating environmental conditions sensed during the course of the infection, and certain riboregulators have already been shown to be crucial for virulence. Some of them are highly conserved among the family Enterobacteriaceae, while others are genus-, species-, or strain-specific and could contribute to the difference in Yersinia pathogenicity. Importantly, the analysis of Yersinia riboregulators has not only uncovered crucial elements and regulatory mechanisms governing host-pathogen interactions, it also revealed exciting new venues for the design of novel anti-infectives.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
RNA Regulators: Formidable Modulators of Yersinia Virulence. 2017, 25 (1):19-34 Trends Microbiol.
Journal:
Trends in microbiology
Issue Date:
Jan-2017
URI:
http://hdl.handle.net/10033/620878
DOI:
10.1016/j.tim.2016.08.006
PubMed ID:
27651123
Type:
Article
Language:
en
ISSN:
1878-4380
Appears in Collections:
publications of the department of molecular Infectionbiology (MIBI)

Full metadata record

DC FieldValue Language
dc.contributor.authorNuss, Aaron Men
dc.contributor.authorHeroven, Ann Kathrinen
dc.contributor.authorDersch, Petraen
dc.date.accessioned2017-04-03T12:11:08Z-
dc.date.available2017-04-03T12:11:08Z-
dc.date.issued2017-01-
dc.identifier.citationRNA Regulators: Formidable Modulators of Yersinia Virulence. 2017, 25 (1):19-34 Trends Microbiol.en
dc.identifier.issn1878-4380-
dc.identifier.pmid27651123-
dc.identifier.doi10.1016/j.tim.2016.08.006-
dc.identifier.urihttp://hdl.handle.net/10033/620878-
dc.description.abstractA large repertoire of RNA-based regulatory mechanisms, including a plethora of cis- and trans-acting noncoding RNAs (ncRNAs), sensory RNA elements, regulatory RNA-binding proteins, and RNA-degrading enzymes have been uncovered lately as key players in the regulation of metabolism, stress responses, and virulence of the genus Yersinia. Many of them are strictly controlled in response to fluctuating environmental conditions sensed during the course of the infection, and certain riboregulators have already been shown to be crucial for virulence. Some of them are highly conserved among the family Enterobacteriaceae, while others are genus-, species-, or strain-specific and could contribute to the difference in Yersinia pathogenicity. Importantly, the analysis of Yersinia riboregulators has not only uncovered crucial elements and regulatory mechanisms governing host-pathogen interactions, it also revealed exciting new venues for the design of novel anti-infectives.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleRNA Regulators: Formidable Modulators of Yersinia Virulence.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalTrends in microbiologyen

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