Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620926
Title:
Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro.
Authors:
Nickel, Sabrina; Selo, Mohammed Ali; Fallack, Juliane; Clerkin, Caoimhe G; Huwer, Hanno; Schneider-Daum, Nicole; Lehr, Claus Michael ( 0000-0002-5864-8462 ) ; Ehrhardt, Carsten
Abstract:
Breast cancer resistance protein (BCRP/ABCG2) has previously been identified with high expression levels in human lung. The subcellular localisation and functional activity of the transporter in lung epithelia, however, remains poorly investigated. The aim of this project was to study BCRP expression and activity in freshly isolated human alveolar epithelial type 2 (AT2) and type 1-like (AT1-like) cells in primary culture, and to compare these findings with data obtained from the NCI-H441 cell line.
Affiliation:
Helmholtz Institut für Pharmaceutischr Forschung Saarland, Universitätscampus E8.1, 66123 Saarbrücken, Germany.
Citation:
Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro. 2017 Pharm. Res.
Journal:
Pharmaceutical research
Issue Date:
3-May-2017
URI:
http://hdl.handle.net/10033/620926
DOI:
10.1007/s11095-017-2172-9
PubMed ID:
28470471
Type:
Article
Language:
en
ISSN:
1573-904X
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorNickel, Sabrinaen
dc.contributor.authorSelo, Mohammed Alien
dc.contributor.authorFallack, Julianeen
dc.contributor.authorClerkin, Caoimhe Gen
dc.contributor.authorHuwer, Hannoen
dc.contributor.authorSchneider-Daum, Nicoleen
dc.contributor.authorLehr, Claus Michaelen
dc.contributor.authorEhrhardt, Carstenen
dc.date.accessioned2017-05-22T11:54:26Z-
dc.date.available2017-05-22T11:54:26Z-
dc.date.issued2017-05-03-
dc.identifier.citationExpression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro. 2017 Pharm. Res.en
dc.identifier.issn1573-904X-
dc.identifier.pmid28470471-
dc.identifier.doi10.1007/s11095-017-2172-9-
dc.identifier.urihttp://hdl.handle.net/10033/620926-
dc.description.abstractBreast cancer resistance protein (BCRP/ABCG2) has previously been identified with high expression levels in human lung. The subcellular localisation and functional activity of the transporter in lung epithelia, however, remains poorly investigated. The aim of this project was to study BCRP expression and activity in freshly isolated human alveolar epithelial type 2 (AT2) and type 1-like (AT1-like) cells in primary culture, and to compare these findings with data obtained from the NCI-H441 cell line.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleExpression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institut für Pharmaceutischr Forschung Saarland, Universitätscampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalPharmaceutical researchen

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