The myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620943
Title:
The myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition.
Authors:
Fleta-Soriano, Eric; Smutná, Katarína; Martinez, Javier P; Lorca Oró, Cristina; Sadiq, S Kashif; Mirambeau, Gilles; Lopez-Iglesias, Carmen; Bosch, Marta; Pol, Albert; Brönstrup, Mark ( 0000-0002-8971-7045 ) ; Diez, Juana; Meyerhans, Andreas
Abstract:
Soraphen A is a myxobacterial metabolite that blocks the acetyl-CoA carboxylase of the host, and was previously identified as a novel HIV inhibitor. Here we report that Soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting inhibition of HIV Env palmitoylation as one of the mechanisms of antiviral action.
Affiliation:
Helmholtz Centre of infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
The myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition. 2017 Antimicrob. Agents Chemother.
Journal:
Antimicrobial agents and chemotherapy
Issue Date:
22-May-2017
URI:
http://hdl.handle.net/10033/620943
DOI:
10.1128/AAC.00739-17
PubMed ID:
28533249
Type:
Article
Language:
en
ISSN:
1098-6596
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorFleta-Soriano, Ericen
dc.contributor.authorSmutná, Katarínaen
dc.contributor.authorMartinez, Javier Pen
dc.contributor.authorLorca Oró, Cristinaen
dc.contributor.authorSadiq, S Kashifen
dc.contributor.authorMirambeau, Gillesen
dc.contributor.authorLopez-Iglesias, Carmenen
dc.contributor.authorBosch, Martaen
dc.contributor.authorPol, Alberten
dc.contributor.authorBrönstrup, Marken
dc.contributor.authorDiez, Juanaen
dc.contributor.authorMeyerhans, Andreasen
dc.date.accessioned2017-06-14T08:39:51Z-
dc.date.available2017-06-14T08:39:51Z-
dc.date.issued2017-05-22-
dc.identifier.citationThe myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition. 2017 Antimicrob. Agents Chemother.en
dc.identifier.issn1098-6596-
dc.identifier.pmid28533249-
dc.identifier.doi10.1128/AAC.00739-17-
dc.identifier.urihttp://hdl.handle.net/10033/620943-
dc.description.abstractSoraphen A is a myxobacterial metabolite that blocks the acetyl-CoA carboxylase of the host, and was previously identified as a novel HIV inhibitor. Here we report that Soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting inhibition of HIV Env palmitoylation as one of the mechanisms of antiviral action.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleThe myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre of infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalAntimicrobial agents and chemotherapyen

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