2.50
Hdl Handle:
http://hdl.handle.net/10033/620979
Title:
Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells.
Authors:
Geis, Franziska K; Galla, Melanie; Hoffmann, Dirk; Kuehle, Johannes; Zychlinski, Daniela; Maetzig, Tobias; Schott, Juliane W; Schwarzer, Adrian; Goffinet, Christine; Goff, Stephen P; Schambach, Axel
Abstract:
Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retrovirus infection due to the presence of active defense mechanisms, or the absence of important cellular host co-factors. In contrast to multipotent stem cells, pluripotent stem cells (PSC) have potential to differentiate into all three germ layers. Much remains to be elucidated in the field of anti-viral immunity in stem cells, especially in PSC.
Affiliation:
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen Str.7, 30625 Hannover, Germany.
Citation:
Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. 2017, 14 (1):34 Retrovirology
Journal:
Retrovirology
Issue Date:
31-May-2017
URI:
http://hdl.handle.net/10033/620979
DOI:
10.1186/s12977-017-0358-1
PubMed ID:
28569216
Type:
Article
Language:
en
ISSN:
1742-4690
Appears in Collections:
publications of the research group innate immunity and viral evasion ([TC] AIVE)

Full metadata record

DC FieldValue Language
dc.contributor.authorGeis, Franziska Ken
dc.contributor.authorGalla, Melanieen
dc.contributor.authorHoffmann, Dirken
dc.contributor.authorKuehle, Johannesen
dc.contributor.authorZychlinski, Danielaen
dc.contributor.authorMaetzig, Tobiasen
dc.contributor.authorSchott, Juliane Wen
dc.contributor.authorSchwarzer, Adrianen
dc.contributor.authorGoffinet, Christineen
dc.contributor.authorGoff, Stephen Pen
dc.contributor.authorSchambach, Axelen
dc.date.accessioned2017-06-26T13:04:52Z-
dc.date.available2017-06-26T13:04:52Z-
dc.date.issued2017-05-31-
dc.identifier.citationPotent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. 2017, 14 (1):34 Retrovirologyen
dc.identifier.issn1742-4690-
dc.identifier.pmid28569216-
dc.identifier.doi10.1186/s12977-017-0358-1-
dc.identifier.urihttp://hdl.handle.net/10033/620979-
dc.description.abstractRetroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retrovirus infection due to the presence of active defense mechanisms, or the absence of important cellular host co-factors. In contrast to multipotent stem cells, pluripotent stem cells (PSC) have potential to differentiate into all three germ layers. Much remains to be elucidated in the field of anti-viral immunity in stem cells, especially in PSC.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titlePotent and reversible lentiviral vector restriction in murine induced pluripotent stem cells.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen Str.7, 30625 Hannover, Germany.en
dc.identifier.journalRetrovirologyen

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