Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620981
Title:
Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.
Authors:
Bankwitz, Dorothea; Doepke, Mandy; Hueging, Kathrin; Weller, Romy; Bruening, Janina; Behrendt, Patrick; Lee, Ji-Young; Vondran, Florian W R; Manns, Michael P ( 0000-0002-4485-8856 ) ; Bartenschlager, Ralf; Pietschmann, Thomas ( 0000-0001-5138-6239 )
Abstract:
Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from non-infected cells interacts with and modulates secreted HCV particles.
Affiliation:
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen Str.7, 30625 Hannover, Germany.
Citation:
Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity. 2017 J. Hepatol.
Journal:
Journal of hepatology
Issue Date:
22-Apr-2017
URI:
http://hdl.handle.net/10033/620981
DOI:
10.1016/j.jhep.2017.04.010
PubMed ID:
28438690
Type:
Article
Language:
en
ISSN:
1600-0641
Appears in Collections:
publications of the department experimental Virology([TC]EVIR)

Full metadata record

DC FieldValue Language
dc.contributor.authorBankwitz, Dorotheaen
dc.contributor.authorDoepke, Mandyen
dc.contributor.authorHueging, Kathrinen
dc.contributor.authorWeller, Romyen
dc.contributor.authorBruening, Janinaen
dc.contributor.authorBehrendt, Patricken
dc.contributor.authorLee, Ji-Youngen
dc.contributor.authorVondran, Florian W Ren
dc.contributor.authorManns, Michael Pen
dc.contributor.authorBartenschlager, Ralfen
dc.contributor.authorPietschmann, Thomasen
dc.date.accessioned2017-06-26T14:37:58Z-
dc.date.available2017-06-26T14:37:58Z-
dc.date.issued2017-04-22-
dc.identifier.citationMaturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity. 2017 J. Hepatol.en
dc.identifier.issn1600-0641-
dc.identifier.pmid28438690-
dc.identifier.doi10.1016/j.jhep.2017.04.010-
dc.identifier.urihttp://hdl.handle.net/10033/620981-
dc.description.abstractHepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from non-infected cells interacts with and modulates secreted HCV particles.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMaturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen Str.7, 30625 Hannover, Germany.en
dc.identifier.journalJournal of hepatologyen

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