Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621001
Title:
Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.
Authors:
Westendorf, Astrid M; Skibbe, Kathrin; Adamczyk, Alexandra; Buer, Jan; Geffers, Robert ( 0000-0003-4409-016X ) ; Hansen, Wiebke; Pastille, Eva; Jendrossek, Verena
Abstract:
Hypoxia occurs in many pathological conditions, including inflammation and cancer. Within this context, hypoxia was shown to inhibit but also to promote T cell responses. Due to this controversial function, we aimed to explore whether an insufficient anti-tumour response during colitis-associated colon cancer could be ascribed to a hypoxic microenvironment.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity. 2017, 41 (4):1271-1284 Cell. Physiol. Biochem.
Journal:
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Issue Date:
2017
URI:
http://hdl.handle.net/10033/621001
DOI:
10.1159/000464429
PubMed ID:
28278498
Type:
Article
Language:
en
ISSN:
1421-9778
Appears in Collections:
publications of the research group genomeanalytics (GMAK)

Full metadata record

DC FieldValue Language
dc.contributor.authorWestendorf, Astrid Men
dc.contributor.authorSkibbe, Kathrinen
dc.contributor.authorAdamczyk, Alexandraen
dc.contributor.authorBuer, Janen
dc.contributor.authorGeffers, Roberten
dc.contributor.authorHansen, Wiebkeen
dc.contributor.authorPastille, Evaen
dc.contributor.authorJendrossek, Verenaen
dc.date.accessioned2017-07-10T12:52:15Z-
dc.date.available2017-07-10T12:52:15Z-
dc.date.issued2017-
dc.identifier.citationHypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity. 2017, 41 (4):1271-1284 Cell. Physiol. Biochem.en
dc.identifier.issn1421-9778-
dc.identifier.pmid28278498-
dc.identifier.doi10.1159/000464429-
dc.identifier.urihttp://hdl.handle.net/10033/621001-
dc.description.abstractHypoxia occurs in many pathological conditions, including inflammation and cancer. Within this context, hypoxia was shown to inhibit but also to promote T cell responses. Due to this controversial function, we aimed to explore whether an insufficient anti-tumour response during colitis-associated colon cancer could be ascribed to a hypoxic microenvironment.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshCell Differentiationen
dc.subject.meshCell Hypoxiaen
dc.subject.meshColitisen
dc.subject.meshColonic Neoplasmsen
dc.subject.meshHypoxia-Inducible Factor 1, alpha Subuniten
dc.subject.meshImmune Toleranceen
dc.subject.meshImmunologic Surveillanceen
dc.subject.meshInterferon-gammaen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshMice, Transgenicen
dc.subject.meshT-Lymphocytes, Regulatoryen
dc.titleHypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyen

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