Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621036
Title:
Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis.
Authors:
Helaly, Soleiman E ( 0000-0002-2159-478X ) ; Kuephadungphan, Wilawan; Phongpaichit, Souwalak; Luangsa-Ard, Janet Jennifer; Rukachaisirikul, Vatcharin; Stadler, Marc ( 0000-0002-7284-8671 )
Abstract:
Five new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3-5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis. 2017, 22 (6) Molecules
Journal:
Molecules (Basel, Switzerland)
Issue Date:
14-Jun-2017
URI:
http://hdl.handle.net/10033/621036
DOI:
10.3390/molecules22060991
PubMed ID:
28613244
Type:
Article
Language:
en
ISSN:
1420-3049
Appears in Collections:
publications of the department of microbial drugs (MWIS)

Full metadata record

DC FieldValue Language
dc.contributor.authorHelaly, Soleiman Een
dc.contributor.authorKuephadungphan, Wilawanen
dc.contributor.authorPhongpaichit, Souwalaken
dc.contributor.authorLuangsa-Ard, Janet Jenniferen
dc.contributor.authorRukachaisirikul, Vatcharinen
dc.contributor.authorStadler, Marcen
dc.date.accessioned2017-08-03T12:44:13Z-
dc.date.available2017-08-03T12:44:13Z-
dc.date.issued2017-06-14-
dc.identifier.citationFive Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis. 2017, 22 (6) Moleculesen
dc.identifier.issn1420-3049-
dc.identifier.pmid28613244-
dc.identifier.doi10.3390/molecules22060991-
dc.identifier.urihttp://hdl.handle.net/10033/621036-
dc.description.abstractFive new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3-5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleFive Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalMolecules (Basel, Switzerland)en

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