Akanthopyrones A-D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621038
Title:
Akanthopyrones A-D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis.
Authors:
Kuephadungphan, Wilawan; Helaly, Soleiman E ( 0000-0002-2159-478X ) ; Daengrot, Charuwan; Phongpaichit, Souwalak; Luangsa-Ard, Janet Jennifer; Rukachaisirikul, Vatcharin; Stadler, Marc ( 0000-0002-7284-8671 )
Abstract:
Hypocrealean fungi have proved to be prolific bioactive metabolite producers; they have caught the attention of mycologists throughout the world. However, only a few studies on the insect and spider parasitic genus Akanthomyces have so far been carried out. In this study, we report the isolation, structural elucidation and biological activities of four unprecedented glycosylated α-pyrone derivatives, akanthopyrones A-D (1-4), from a culture of Akanthomyces novoguineensis collected in Thailand. The chemical structures of the akanthopyrones were determined by extensive 1D- and 2D-NMR, and HRMS spectroscopic analysis. Their absolute configurations were determined. Akanthopyrone A (1) exhibited weak antimicrobial activity against Bacillus subtilis DSM10 and cytotoxicity against the HeLa cell line KB-3-1, while akanthopyrone D (4) showed weak activity against Candida tenuis MUCL 29892.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Akanthopyrones A-D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis. 2017, 22 (7) Molecules
Journal:
Molecules (Basel, Switzerland)
Issue Date:
18-Jul-2017
URI:
http://hdl.handle.net/10033/621038
DOI:
10.3390/molecules22071202
PubMed ID:
28718819
Type:
Article
Language:
en
ISSN:
1420-3049
Appears in Collections:
publications of the department of microbial drugs (MWIS)

Full metadata record

DC FieldValue Language
dc.contributor.authorKuephadungphan, Wilawanen
dc.contributor.authorHelaly, Soleiman Een
dc.contributor.authorDaengrot, Charuwanen
dc.contributor.authorPhongpaichit, Souwalaken
dc.contributor.authorLuangsa-Ard, Janet Jenniferen
dc.contributor.authorRukachaisirikul, Vatcharinen
dc.contributor.authorStadler, Marcen
dc.date.accessioned2017-08-03T13:19:28Z-
dc.date.available2017-08-03T13:19:28Z-
dc.date.issued2017-07-18-
dc.identifier.citationAkanthopyrones A-D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis. 2017, 22 (7) Moleculesen
dc.identifier.issn1420-3049-
dc.identifier.pmid28718819-
dc.identifier.doi10.3390/molecules22071202-
dc.identifier.urihttp://hdl.handle.net/10033/621038-
dc.description.abstractHypocrealean fungi have proved to be prolific bioactive metabolite producers; they have caught the attention of mycologists throughout the world. However, only a few studies on the insect and spider parasitic genus Akanthomyces have so far been carried out. In this study, we report the isolation, structural elucidation and biological activities of four unprecedented glycosylated α-pyrone derivatives, akanthopyrones A-D (1-4), from a culture of Akanthomyces novoguineensis collected in Thailand. The chemical structures of the akanthopyrones were determined by extensive 1D- and 2D-NMR, and HRMS spectroscopic analysis. Their absolute configurations were determined. Akanthopyrone A (1) exhibited weak antimicrobial activity against Bacillus subtilis DSM10 and cytotoxicity against the HeLa cell line KB-3-1, while akanthopyrone D (4) showed weak activity against Candida tenuis MUCL 29892.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleAkanthopyrones A-D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalMolecules (Basel, Switzerland)en

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