2.50
Hdl Handle:
http://hdl.handle.net/10033/621055
Title:
The German National Cohort: aims, study design and organization.
Authors:
German National Cohort consortium; Krause, Gerard ( 0000-0003-3328-8808 )
Abstract:
The German National Cohort (GNC) is a joint interdisciplinary endeavour of scientists from the Helmholtz and the Leibniz Association, universities, and other research institutes. Its aim is to investigate the causes for the development of major chronic diseases, i.e. cardiovascular diseases, cancer, diabetes, neurodegenerative/-psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases, and their pre-clinical stages or functional health impairments. Across Germany, a random sample of the general population will be drawn by 18 regional study centres, including a total of 100,000 women and 100,000 men aged 20-69 years. The baseline assessments include an extensive interview and self-completion questionnaires, a wide range of medical examinations and the collection of various biomaterials. In a random subgroup of 20 % of the participants (n = 40,000) an intensified examination ("Level 2") programme will be performed. In addition, in five of the 18 study centres a total of 30,000 study participants will take part in a magnetic resonance imaging examination programme, and all of these participants will also be offered the intensified Level 2 examinations. After 4-5 years, all participants will be invited for a re-assessment. Information about chronic disease endpoints will be collected through a combination of active follow-up (including questionnaires every 2-3 years) and record linkages. The GNC is planned for an overall duration of 25-30 years. It will provide a major, central resource for population-based epidemiology in Germany, and will help to identify new and tailored strategies for early detection, prediction, and primary prevention of major diseases.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
The German National Cohort: aims, study design and organization. 2014, 29 (5):371-82 Eur. J. Epidemiol.
Journal:
European journal of epidemiology
Issue Date:
May-2014
URI:
http://hdl.handle.net/10033/621055
DOI:
10.1007/s10654-014-9890-7
PubMed ID:
24840228
Type:
Article
Language:
en
ISSN:
1573-7284
Appears in Collections:
Publications of the department of epidemiology (EPID)

Full metadata record

DC FieldValue Language
dc.contributor.authorGerman National Cohort consortiumen
dc.contributor.authorKrause, Gerarden
dc.date.accessioned2017-08-16T07:55:14Z-
dc.date.available2017-08-16T07:55:14Z-
dc.date.issued2014-05-
dc.identifier.citationThe German National Cohort: aims, study design and organization. 2014, 29 (5):371-82 Eur. J. Epidemiol.en
dc.identifier.issn1573-7284-
dc.identifier.pmid24840228-
dc.identifier.doi10.1007/s10654-014-9890-7-
dc.identifier.urihttp://hdl.handle.net/10033/621055-
dc.description.abstractThe German National Cohort (GNC) is a joint interdisciplinary endeavour of scientists from the Helmholtz and the Leibniz Association, universities, and other research institutes. Its aim is to investigate the causes for the development of major chronic diseases, i.e. cardiovascular diseases, cancer, diabetes, neurodegenerative/-psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases, and their pre-clinical stages or functional health impairments. Across Germany, a random sample of the general population will be drawn by 18 regional study centres, including a total of 100,000 women and 100,000 men aged 20-69 years. The baseline assessments include an extensive interview and self-completion questionnaires, a wide range of medical examinations and the collection of various biomaterials. In a random subgroup of 20 % of the participants (n = 40,000) an intensified examination ("Level 2") programme will be performed. In addition, in five of the 18 study centres a total of 30,000 study participants will take part in a magnetic resonance imaging examination programme, and all of these participants will also be offered the intensified Level 2 examinations. After 4-5 years, all participants will be invited for a re-assessment. Information about chronic disease endpoints will be collected through a combination of active follow-up (including questionnaires every 2-3 years) and record linkages. The GNC is planned for an overall duration of 25-30 years. It will provide a major, central resource for population-based epidemiology in Germany, and will help to identify new and tailored strategies for early detection, prediction, and primary prevention of major diseases.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshChronic Diseaseen
dc.subject.meshCohort Studiesen
dc.subject.meshDiseaseen
dc.subject.meshFemaleen
dc.subject.meshGermanyen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPopulation Surveillanceen
dc.subject.meshResearch Designen
dc.subject.meshYoung Adulten
dc.titleThe German National Cohort: aims, study design and organization.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalEuropean journal of epidemiologyen

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