HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621064
Title:
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
Authors:
Raza, Syed Ahsan; Albrecht, Anne; Çalışkan, Gürsel; Müller, Bettina; Demiray, Yunus Emre; Ludewig, Susann; Meis, Susanne; Faber, Nicolai; Hartig, Roland; Schraven, Burkhart; Lessmann, Volkmar; Schwegler, Herbert; Stork, Oliver
Abstract:
Cholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition.Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST(+) interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY(+) hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. 2017, 8 (1):189 Nat Commun
Journal:
Nature communications
Issue Date:
4-Aug-2017
URI:
http://hdl.handle.net/10033/621064
DOI:
10.1038/s41467-017-00205-3
PubMed ID:
28775269
Type:
Article
Language:
en
ISSN:
2041-1723
Appears in Collections:
publications of the department of immune control (IMMK)

Full metadata record

DC FieldValue Language
dc.contributor.authorRaza, Syed Ahsanen
dc.contributor.authorAlbrecht, Anneen
dc.contributor.authorÇalışkan, Gürselen
dc.contributor.authorMüller, Bettinaen
dc.contributor.authorDemiray, Yunus Emreen
dc.contributor.authorLudewig, Susannen
dc.contributor.authorMeis, Susanneen
dc.contributor.authorFaber, Nicolaien
dc.contributor.authorHartig, Rolanden
dc.contributor.authorSchraven, Burkharten
dc.contributor.authorLessmann, Volkmaren
dc.contributor.authorSchwegler, Herberten
dc.contributor.authorStork, Oliveren
dc.date.accessioned2017-08-17T13:26:03Z-
dc.date.available2017-08-17T13:26:03Z-
dc.date.issued2017-08-04-
dc.identifier.citationHIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. 2017, 8 (1):189 Nat Communen
dc.identifier.issn2041-1723-
dc.identifier.pmid28775269-
dc.identifier.doi10.1038/s41467-017-00205-3-
dc.identifier.urihttp://hdl.handle.net/10033/621064-
dc.description.abstractCholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition.Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST(+) interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY(+) hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleHIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalNature communicationsen
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