2.50
Hdl Handle:
http://hdl.handle.net/10033/621081
Title:
Bacterial Inclusion Bodies: Discovering Their Better Half.
Authors:
Rinas, Ursula; Garcia-Fruitós, Elena; Corchero, José Luis; Vázquez, Esther; Seras-Franzoso, Joaquin; Villaverde, Antonio ( 0000-0002-2615-4521 )
Abstract:
Bacterial inclusion bodies (IBs) are functional, non-toxic amyloids occurring in recombinant bacteria showing analogies with secretory granules of the mammalian endocrine system. The scientific interest in these mesoscale protein aggregates has been historically masked by their status as a hurdle in recombinant protein production. However, progressive understanding of how the cell handles the quality of recombinant polypeptides and the main features of their intriguing molecular organization has stimulated the interest in inclusion bodies and spurred their use in diverse technological fields. The engineering and tailoring of IBs as functional protein particles for materials science and biomedicine is a good example of how formerly undesired bacterial byproducts can be rediscovered as promising functional materials for a broad spectrum of applications.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Bacterial Inclusion Bodies: Discovering Their Better Half. 2017 Trends Biochem. Sci.
Journal:
Trends in biochemical sciences
Issue Date:
27-Feb-2017
URI:
http://hdl.handle.net/10033/621081
DOI:
10.1016/j.tibs.2017.01.005
PubMed ID:
28254353
Type:
Article
Language:
en
ISSN:
0968-0004
Appears in Collections:
Publications of Scientific Director (GFW)

Full metadata record

DC FieldValue Language
dc.contributor.authorRinas, Ursulaen
dc.contributor.authorGarcia-Fruitós, Elenaen
dc.contributor.authorCorchero, José Luisen
dc.contributor.authorVázquez, Estheren
dc.contributor.authorSeras-Franzoso, Joaquinen
dc.contributor.authorVillaverde, Antonioen
dc.date.accessioned2017-08-31T12:45:44Z-
dc.date.available2017-08-31T12:45:44Z-
dc.date.issued2017-02-27-
dc.identifier.citationBacterial Inclusion Bodies: Discovering Their Better Half. 2017 Trends Biochem. Sci.en
dc.identifier.issn0968-0004-
dc.identifier.pmid28254353-
dc.identifier.doi10.1016/j.tibs.2017.01.005-
dc.identifier.urihttp://hdl.handle.net/10033/621081-
dc.description.abstractBacterial inclusion bodies (IBs) are functional, non-toxic amyloids occurring in recombinant bacteria showing analogies with secretory granules of the mammalian endocrine system. The scientific interest in these mesoscale protein aggregates has been historically masked by their status as a hurdle in recombinant protein production. However, progressive understanding of how the cell handles the quality of recombinant polypeptides and the main features of their intriguing molecular organization has stimulated the interest in inclusion bodies and spurred their use in diverse technological fields. The engineering and tailoring of IBs as functional protein particles for materials science and biomedicine is a good example of how formerly undesired bacterial byproducts can be rediscovered as promising functional materials for a broad spectrum of applications.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleBacterial Inclusion Bodies: Discovering Their Better Half.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalTrends in biochemical sciencesen

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