Optimization of the biotechnological production of a novel class of anti-MRSA antibiotics from Chitinophaga sancti.
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Issue Date
2017-08-17
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Show full item recordAbstract
Recently, the discovery of the elansolids, a group of macrolides, was reported. The molecules show activity against methicillin-resistant Staphylococcus aureus as well as other gram-positive organisms. This fact renders those substances a promising starting point for future chemical development. The active atropisomers A1/A2 are formed by macrolactonization of the biosynthesis product A3 but are prone to ring opening and subsequent formation of several unwanted side products. Recently it could be shown that addition of different nucleophiles to culture extracts of Chitinophaga sancti enable the formation of new stable elansolid derivatives. Furthermore, addition of such a nucleophile directly into the culture led exclusively to formation of a single active elansolid derivative. Due to low product yields, methods for production of gram amounts of these molecules have to be established to enable further development of this promising compound class.Citation
Optimization of the biotechnological production of a novel class of anti-MRSA antibiotics from Chitinophaga sancti. 2017, 16 (1):143 Microb. Cell Fact.Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.Journal
Microbial cell factoriesPubMed ID
28818083Type
ArticleLanguage
enISSN
1475-2859ae974a485f413a2113503eed53cd6c53
10.1186/s12934-017-0756-z
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/