Structure-functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621112
Title:
Structure-functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators.
Authors:
Kamal, Ahmed A M; Petrera, Lucia; Eberhard, Jens; Hartmann, Rolf W.
Abstract:
An important paradigm in anti-infective research is the antivirulence concept. Pathoblockers are compounds which disarm bacteria of their arsenal of virulence factors. PqsR is a transcriptional regulator controlling the production of such factors in Pseudomonas aeruginosa, most prominently pyocyanin. In this work, a series of tool compounds based on the structure of the natural ligand 2-heptyl-4-quinolone (HHQ) were used for probing the structure-functionality relationship. Four different profiles are identified namely agonists, antagonists, inverse agonists and biphasic modulators. Molecular docking studies revealed that each class of the PqsR modulators showed distinctive interactions in the PqsR binding domain. It was found that the substituents in position 3 of the quinolone core act as a switch between the different profiles, according to their ability to donate or accept a hydrogen bond, or form a hydrophobic interaction. Finally, it was shown that only inverse agonists were able to strongly inhibit pyocyanin production.
Affiliation:
Helmholtz-Institu für pharmazeutische Forschung Saarland,, Universitätscampus E8.1, 66123 Saarbrücken, Germany.
Citation:
Structure-functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators. 2017, 15 (21):4620-4630 Org. Biomol. Chem.
Journal:
Organic & biomolecular chemistry
Issue Date:
31-May-2017
URI:
http://hdl.handle.net/10033/621112
DOI:
10.1039/c7ob00263g
PubMed ID:
28513746
Type:
Article
Language:
en
ISSN:
1477-0539
Appears in Collections:
publications of the department drug design and optimization (HIPS]DDOP)

Full metadata record

DC FieldValue Language
dc.contributor.authorKamal, Ahmed A Men
dc.contributor.authorPetrera, Luciaen
dc.contributor.authorEberhard, Jensen
dc.contributor.authorHartmann, Rolf W.en
dc.date.accessioned2017-09-18T12:58:35Z-
dc.date.available2017-09-18T12:58:35Z-
dc.date.issued2017-05-31-
dc.identifier.citationStructure-functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators. 2017, 15 (21):4620-4630 Org. Biomol. Chem.en
dc.identifier.issn1477-0539-
dc.identifier.pmid28513746-
dc.identifier.doi10.1039/c7ob00263g-
dc.identifier.urihttp://hdl.handle.net/10033/621112-
dc.description.abstractAn important paradigm in anti-infective research is the antivirulence concept. Pathoblockers are compounds which disarm bacteria of their arsenal of virulence factors. PqsR is a transcriptional regulator controlling the production of such factors in Pseudomonas aeruginosa, most prominently pyocyanin. In this work, a series of tool compounds based on the structure of the natural ligand 2-heptyl-4-quinolone (HHQ) were used for probing the structure-functionality relationship. Four different profiles are identified namely agonists, antagonists, inverse agonists and biphasic modulators. Molecular docking studies revealed that each class of the PqsR modulators showed distinctive interactions in the PqsR binding domain. It was found that the substituents in position 3 of the quinolone core act as a switch between the different profiles, according to their ability to donate or accept a hydrogen bond, or form a hydrophobic interaction. Finally, it was shown that only inverse agonists were able to strongly inhibit pyocyanin production.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleStructure-functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institu für pharmazeutische Forschung Saarland,, Universitätscampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalOrganic & biomolecular chemistryen

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