Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621143
Title:
Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells.
Authors:
Ribeiro, Giovanni Monteiro; Matsumoto, Cristianne Kayoko; Real, Fernando; Teixeira, Daniela; Duarte, Rafael Silva; Mortara, Renato Arruda; Leão, Sylvia Cardoso; de Souza Carvalho-Wodarz, Cristiane
Abstract:
Outbreaks of infections caused by rapidly growing mycobacteria have been reported worldwide generally associated with medical procedures. Mycobacterium abscessus subsp. massiliense CRM0019 was obtained during an epidemic of postsurgical infections and was characterized by increased persistence in vivo. To better understand the successful survival strategies of this microorganism, we evaluated its infectivity and proliferation in macrophages (RAW and BMDM) and alveolar epithelial cells (A549). For that, we assessed the following parameters, for both M. abscessus CRM0019 as well as the reference strain M. abscessus ATCC 19977: internalization, intracellular survival for up 3 days, competence to subvert lysosome fusion and the intracellular survival after cell reinfection.
Affiliation:
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Universitycampus E8.1, 66123 Saarbrücken, Germany.
Citation:
Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells. 2017, 17 (1):195 BMC Microbiol.
Journal:
BMC microbiology
Issue Date:
13-Sep-2017
URI:
http://hdl.handle.net/10033/621143
DOI:
10.1186/s12866-017-1102-7
PubMed ID:
28903728
Type:
Article
Language:
en
ISSN:
1471-2180
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorRibeiro, Giovanni Monteiroen
dc.contributor.authorMatsumoto, Cristianne Kayokoen
dc.contributor.authorReal, Fernandoen
dc.contributor.authorTeixeira, Danielaen
dc.contributor.authorDuarte, Rafael Silvaen
dc.contributor.authorMortara, Renato Arrudaen
dc.contributor.authorLeão, Sylvia Cardosoen
dc.contributor.authorde Souza Carvalho-Wodarz, Cristianeen
dc.date.accessioned2017-10-24T08:43:03Z-
dc.date.available2017-10-24T08:43:03Z-
dc.date.issued2017-09-13-
dc.identifier.citationIncreased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells. 2017, 17 (1):195 BMC Microbiol.en
dc.identifier.issn1471-2180-
dc.identifier.pmid28903728-
dc.identifier.doi10.1186/s12866-017-1102-7-
dc.identifier.urihttp://hdl.handle.net/10033/621143-
dc.description.abstractOutbreaks of infections caused by rapidly growing mycobacteria have been reported worldwide generally associated with medical procedures. Mycobacterium abscessus subsp. massiliense CRM0019 was obtained during an epidemic of postsurgical infections and was characterized by increased persistence in vivo. To better understand the successful survival strategies of this microorganism, we evaluated its infectivity and proliferation in macrophages (RAW and BMDM) and alveolar epithelial cells (A549). For that, we assessed the following parameters, for both M. abscessus CRM0019 as well as the reference strain M. abscessus ATCC 19977: internalization, intracellular survival for up 3 days, competence to subvert lysosome fusion and the intracellular survival after cell reinfection.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleIncreased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Universitycampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalBMC microbiologyen

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