2.50
Hdl Handle:
http://hdl.handle.net/10033/621147
Title:
Saccharide-Containing Dynamic Proteoids.
Authors:
Liu, Yun; Stuart, Marc C A; Witte, Martin D; Buhler, Eric; Hirsch, Anna K H
Abstract:
Dynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar-containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological aliphatic dialdehyde and a nonbiological aromatic dialdehyde. By using the saccharide-based dialdehyde, the biocompatibility of biodynamers should be enhanced compared to previously reported biodynamers.
Affiliation:
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Universitycampus E8.1, 66123 Saarbrücken, Germany.
Citation:
Saccharide-Containing Dynamic Proteoids. 2017 Chemistry
Journal:
Chemistry (Weinheim an der Bergstrasse, Germany)
Issue Date:
5-Oct-2017
URI:
http://hdl.handle.net/10033/621147
DOI:
10.1002/chem.201703584
PubMed ID:
28981987
Type:
Article
Language:
en
ISSN:
1521-3765
Appears in Collections:
publications of the department drug design and optimization (HIPS]DDOP)

Full metadata record

DC FieldValue Language
dc.contributor.authorLiu, Yunen
dc.contributor.authorStuart, Marc C Aen
dc.contributor.authorWitte, Martin Den
dc.contributor.authorBuhler, Ericen
dc.contributor.authorHirsch, Anna K Hen
dc.date.accessioned2017-11-01T08:31:27Z-
dc.date.available2017-11-01T08:31:27Z-
dc.date.issued2017-10-05-
dc.identifier.citationSaccharide-Containing Dynamic Proteoids. 2017 Chemistryen
dc.identifier.issn1521-3765-
dc.identifier.pmid28981987-
dc.identifier.doi10.1002/chem.201703584-
dc.identifier.urihttp://hdl.handle.net/10033/621147-
dc.description.abstractDynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar-containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological aliphatic dialdehyde and a nonbiological aromatic dialdehyde. By using the saccharide-based dialdehyde, the biocompatibility of biodynamers should be enhanced compared to previously reported biodynamers.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleSaccharide-Containing Dynamic Proteoids.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Universitycampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalChemistry (Weinheim an der Bergstrasse, Germany)en

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