2.50
Hdl Handle:
http://hdl.handle.net/10033/621150
Title:
Actin assembly mechanisms at a glance.
Authors:
Rottner, Klemens; Faix, Jan; Bogdan, Sven; Linder, Stefan; Kerkhoff, Eugen
Abstract:
The actin cytoskeleton and associated motor proteins provide the driving forces for establishing the astonishing morphological diversity and dynamics of mammalian cells. Aside from functions in protruding and contracting cell membranes for motility, differentiation or cell division, the actin cytoskeleton provides forces to shape and move intracellular membranes of organelles and vesicles. To establish the many different actin assembly functions required in time and space, actin nucleators are targeted to specific subcellular compartments, thereby restricting the generation of specific actin filament structures to those sites. Recent research has revealed that targeting and activation of actin filament nucleators, elongators and myosin motors are tightly coordinated by conserved protein complexes to orchestrate force generation. In this Cell Science at a Glance article and the accompanying poster, we summarize and discuss the current knowledge on the corresponding protein complexes and their modes of action in actin nucleation, elongation and force generation.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Actin assembly mechanisms at a glance. 2017, 130 (20):3427-3435 J. Cell. Sci.
Journal:
Journal of cell science
Issue Date:
15-Oct-2017
URI:
http://hdl.handle.net/10033/621150
DOI:
10.1242/jcs.206433
PubMed ID:
29032357
Type:
Article
Language:
en
ISSN:
1477-9137
Appears in Collections:
publications of the Research group: molecular cell biology (MZBI)

Full metadata record

DC FieldValue Language
dc.contributor.authorRottner, Klemensen
dc.contributor.authorFaix, Janen
dc.contributor.authorBogdan, Svenen
dc.contributor.authorLinder, Stefanen
dc.contributor.authorKerkhoff, Eugenen
dc.date.accessioned2017-11-01T12:38:45Z-
dc.date.available2017-11-01T12:38:45Z-
dc.date.issued2017-10-15-
dc.identifier.citationActin assembly mechanisms at a glance. 2017, 130 (20):3427-3435 J. Cell. Sci.en
dc.identifier.issn1477-9137-
dc.identifier.pmid29032357-
dc.identifier.doi10.1242/jcs.206433-
dc.identifier.urihttp://hdl.handle.net/10033/621150-
dc.description.abstractThe actin cytoskeleton and associated motor proteins provide the driving forces for establishing the astonishing morphological diversity and dynamics of mammalian cells. Aside from functions in protruding and contracting cell membranes for motility, differentiation or cell division, the actin cytoskeleton provides forces to shape and move intracellular membranes of organelles and vesicles. To establish the many different actin assembly functions required in time and space, actin nucleators are targeted to specific subcellular compartments, thereby restricting the generation of specific actin filament structures to those sites. Recent research has revealed that targeting and activation of actin filament nucleators, elongators and myosin motors are tightly coordinated by conserved protein complexes to orchestrate force generation. In this Cell Science at a Glance article and the accompanying poster, we summarize and discuss the current knowledge on the corresponding protein complexes and their modes of action in actin nucleation, elongation and force generation.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleActin assembly mechanisms at a glance.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of cell scienceen

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