Identification of a novel subset of myeloid-derived suppressor cells during chronic staphylococcal infection that resembles immature eosinophils.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621156
Title:
Identification of a novel subset of myeloid-derived suppressor cells during chronic staphylococcal infection that resembles immature eosinophils.
Authors:
Goldmann, Oliver; Beineke, Andreas; Medina, Eva
Abstract:
We have previously reported that myeloid-derived suppressor cells (MDSC), which are a heterogeneous population of immunosuppressive immature myeloid cells, expanded during chronic Staphylococcus aureus infection and promoted bacterial persistence by inhibiting effector T cells. Two major MDSC subsets including monocytic MDSCs (M-MDSC) and granulocytic MDSCs (G-MDSC) have been described to date. Here, we identified a new subset of MDSC (Eo-MDSC) in S. aureus-infected mice that phenotypically resembles eosinophils. Eo-MDSC exhibit eosinophilic cytoplasmic granules and express CD11b, the eosinophil marker Syglec-F, variable levels of CCR3 and low levels of IL-5R. Furthermore, Eo-MDSC accumulated at the site of infection and exerted a potent immunosuppressive effect on T cell responses that was mediated by nitric oxide-dependent depletion of L-arginine. Increased in the number of Eo-MDSC by adoptive transfer caused a significant exacerbation of infection in S. aureus-infected mice. This study sheds new light on the heterogeneity and complexity of MDSC during chronic infection.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunchweig, Germany.
Citation:
Identification of a novel subset of myeloid-derived suppressor cells during chronic staphylococcal infection that resembles immature eosinophils. 2017 J. Infect. Dis.
Journal:
The Journal of infectious diseases
Issue Date:
23-Sep-2017
URI:
http://hdl.handle.net/10033/621156
DOI:
10.1093/infdis/jix494
PubMed ID:
29029332
Type:
Article
Language:
en
ISSN:
1537-6613
Appears in Collections:
publications of the research group immunology of infection (INI)

Full metadata record

DC FieldValue Language
dc.contributor.authorGoldmann, Oliveren
dc.contributor.authorBeineke, Andreasen
dc.contributor.authorMedina, Evaen
dc.date.accessioned2017-11-02T15:23:27Z-
dc.date.available2017-11-02T15:23:27Z-
dc.date.issued2017-09-23-
dc.identifier.citationIdentification of a novel subset of myeloid-derived suppressor cells during chronic staphylococcal infection that resembles immature eosinophils. 2017 J. Infect. Dis.en
dc.identifier.issn1537-6613-
dc.identifier.pmid29029332-
dc.identifier.doi10.1093/infdis/jix494-
dc.identifier.urihttp://hdl.handle.net/10033/621156-
dc.description.abstractWe have previously reported that myeloid-derived suppressor cells (MDSC), which are a heterogeneous population of immunosuppressive immature myeloid cells, expanded during chronic Staphylococcus aureus infection and promoted bacterial persistence by inhibiting effector T cells. Two major MDSC subsets including monocytic MDSCs (M-MDSC) and granulocytic MDSCs (G-MDSC) have been described to date. Here, we identified a new subset of MDSC (Eo-MDSC) in S. aureus-infected mice that phenotypically resembles eosinophils. Eo-MDSC exhibit eosinophilic cytoplasmic granules and express CD11b, the eosinophil marker Syglec-F, variable levels of CCR3 and low levels of IL-5R. Furthermore, Eo-MDSC accumulated at the site of infection and exerted a potent immunosuppressive effect on T cell responses that was mediated by nitric oxide-dependent depletion of L-arginine. Increased in the number of Eo-MDSC by adoptive transfer caused a significant exacerbation of infection in S. aureus-infected mice. This study sheds new light on the heterogeneity and complexity of MDSC during chronic infection.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleIdentification of a novel subset of myeloid-derived suppressor cells during chronic staphylococcal infection that resembles immature eosinophils.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunchweig, Germany.en
dc.identifier.journalThe Journal of infectious diseasesen

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