Differential Infection Patterns and Recent Evolutionary Origins of Equine Hepaciviruses in Donkeys.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621159
Title:
Differential Infection Patterns and Recent Evolutionary Origins of Equine Hepaciviruses in Donkeys.
Authors:
Walter, Stephanie; Rasche, Andrea; Moreira-Soto, Andrés; Pfaender, Stephanie; Bletsa, Magda; Corman, Victor Max; Aguilar-Setien, Alvaro; García-Lacy, Fernando; Hans, Aymeric; Todt, Daniel; Schuler, Gerhard; Shnaiderman-Torban, Anat; Steinman, Amir; Roncoroni, Cristina; Veneziano, Vincenzo; Rusenova, Nikolina; Sandev, Nikolay; Rusenov, Anton; Zapryanova, Dimitrinka; García-Bocanegra, Ignacio; Jores, Joerg; Carluccio, Augusto; Veronesi, Maria Cristina; Cavalleri, Jessika M V; Drosten, Christian; Lemey, Philippe; Steinmann, Eike ( 0000-0002-8771-4262 ) ; Drexler, Jan Felix
Abstract:
The hepatitis C virus (HCV) is a major human pathogen. Genetically related viruses in animals suggest a zoonotic origin of HCV. The closest relative of HCV is found in horses (termed equine hepacivirus [EqHV]). However, low EqHV genetic diversity implies relatively recent acquisition of EqHV by horses, making a derivation of HCV from EqHV unlikely. To unravel the EqHV evolutionary history within equid sister species, we analyzed 829 donkeys and 53 mules sampled in nine European, Asian, African, and American countries by molecular and serologic tools for EqHV infection. Antibodies were found in 278 animals (31.5%), and viral RNA was found in 3 animals (0.3%), all of which were simultaneously seropositive. A low RNA prevalence in spite of high seroprevalence suggests a predominance of acute infection, a possible difference from the mostly chronic hepacivirus infection pattern seen in horses and humans. Limitation of transmission due to short courses of infection may explain the existence of entirely seronegative groups of animals. Donkey and horse EqHV strains were paraphyletic and 97.5 to 98.2% identical in their translated polyprotein sequences, making virus/host cospeciation unlikely. Evolutionary reconstructions supported host switches of EqHV between horses and donkeys without the involvement of adaptive evolution. Global admixture of donkey and horse hepaciviruses was compatible with anthropogenic alterations of EqHV ecology. In summary, our findings do not support EqHV as the origin of the significantly more diversified HCV. Identification of a host system with predominantly acute hepacivirus infection may enable new insights into the chronic infection pattern associated with HCV.
Affiliation:
TwinCore, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str.7, 30625 Hannover, Germany.
Citation:
Differential Infection Patterns and Recent Evolutionary Origins of Equine Hepaciviruses in Donkeys. 2017, 91 (1) J. Virol.
Journal:
Journal of virology
Issue Date:
1-Jan-2017
URI:
http://hdl.handle.net/10033/621159
DOI:
10.1128/JVI.01711-16
PubMed ID:
27795428
Type:
Article
Language:
en
ISSN:
1098-5514
Appears in Collections:
publications of the research group virus transmission ([TC]VIRT)

Full metadata record

DC FieldValue Language
dc.contributor.authorWalter, Stephanieen
dc.contributor.authorRasche, Andreaen
dc.contributor.authorMoreira-Soto, Andrésen
dc.contributor.authorPfaender, Stephanieen
dc.contributor.authorBletsa, Magdaen
dc.contributor.authorCorman, Victor Maxen
dc.contributor.authorAguilar-Setien, Alvaroen
dc.contributor.authorGarcía-Lacy, Fernandoen
dc.contributor.authorHans, Aymericen
dc.contributor.authorTodt, Danielen
dc.contributor.authorSchuler, Gerharden
dc.contributor.authorShnaiderman-Torban, Anaten
dc.contributor.authorSteinman, Amiren
dc.contributor.authorRoncoroni, Cristinaen
dc.contributor.authorVeneziano, Vincenzoen
dc.contributor.authorRusenova, Nikolinaen
dc.contributor.authorSandev, Nikolayen
dc.contributor.authorRusenov, Antonen
dc.contributor.authorZapryanova, Dimitrinkaen
dc.contributor.authorGarcía-Bocanegra, Ignacioen
dc.contributor.authorJores, Joergen
dc.contributor.authorCarluccio, Augustoen
dc.contributor.authorVeronesi, Maria Cristinaen
dc.contributor.authorCavalleri, Jessika M Ven
dc.contributor.authorDrosten, Christianen
dc.contributor.authorLemey, Philippeen
dc.contributor.authorSteinmann, Eikeen
dc.contributor.authorDrexler, Jan Felixen
dc.date.accessioned2017-11-03T15:05:53Z-
dc.date.available2017-11-03T15:05:53Z-
dc.date.issued2017-01-01-
dc.identifier.citationDifferential Infection Patterns and Recent Evolutionary Origins of Equine Hepaciviruses in Donkeys. 2017, 91 (1) J. Virol.en
dc.identifier.issn1098-5514-
dc.identifier.pmid27795428-
dc.identifier.doi10.1128/JVI.01711-16-
dc.identifier.urihttp://hdl.handle.net/10033/621159-
dc.description.abstractThe hepatitis C virus (HCV) is a major human pathogen. Genetically related viruses in animals suggest a zoonotic origin of HCV. The closest relative of HCV is found in horses (termed equine hepacivirus [EqHV]). However, low EqHV genetic diversity implies relatively recent acquisition of EqHV by horses, making a derivation of HCV from EqHV unlikely. To unravel the EqHV evolutionary history within equid sister species, we analyzed 829 donkeys and 53 mules sampled in nine European, Asian, African, and American countries by molecular and serologic tools for EqHV infection. Antibodies were found in 278 animals (31.5%), and viral RNA was found in 3 animals (0.3%), all of which were simultaneously seropositive. A low RNA prevalence in spite of high seroprevalence suggests a predominance of acute infection, a possible difference from the mostly chronic hepacivirus infection pattern seen in horses and humans. Limitation of transmission due to short courses of infection may explain the existence of entirely seronegative groups of animals. Donkey and horse EqHV strains were paraphyletic and 97.5 to 98.2% identical in their translated polyprotein sequences, making virus/host cospeciation unlikely. Evolutionary reconstructions supported host switches of EqHV between horses and donkeys without the involvement of adaptive evolution. Global admixture of donkey and horse hepaciviruses was compatible with anthropogenic alterations of EqHV ecology. In summary, our findings do not support EqHV as the origin of the significantly more diversified HCV. Identification of a host system with predominantly acute hepacivirus infection may enable new insights into the chronic infection pattern associated with HCV.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAcute Diseaseen
dc.subject.meshAnimalsen
dc.subject.meshAntibodies, Viralen
dc.subject.meshBiological Evolutionen
dc.subject.meshEquidaeen
dc.subject.meshEuropeen
dc.subject.meshGenetic Variationen
dc.subject.meshGenome, Viralen
dc.subject.meshHepacivirusen
dc.subject.meshHepatitis Cen
dc.subject.meshHorsesen
dc.subject.meshHost Specificityen
dc.subject.meshHumansen
dc.subject.meshIsraelen
dc.subject.meshKenyaen
dc.subject.meshLatin Americaen
dc.subject.meshPhylogenyen
dc.subject.meshSequence Analysis, DNAen
dc.subject.meshSeroepidemiologic Studiesen
dc.titleDifferential Infection Patterns and Recent Evolutionary Origins of Equine Hepaciviruses in Donkeys.en
dc.typeArticleen
dc.contributor.departmentTwinCore, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str.7, 30625 Hannover, Germany.en
dc.identifier.journalJournal of virologyen

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